Edinburgh Research Archive logo

Edinburgh Research Archive

University of Edinburgh homecrest
View Item 
  •   ERA Home
  • Chemistry, School of
  • Chemistry thesis and dissertation collection
  • View Item
  •   ERA Home
  • Chemistry, School of
  • Chemistry thesis and dissertation collection
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Active metal template synthesis of rotaxanes, catenanes and knots

View/Open
word docs.zip (21.81Mb)
McGonigal2010.pdf (24.82Mb)
Date
2011
Author
McGonigal, Paul R.
Metadata
Show full item record
Abstract
The use of a chemical template to control the spatial arrangement of reactants revolutionized the synthesis of mechanically interlocked molecules. The recently developed ‘active metal template’ strategy, in which transition metal ions act as both the template to guide interlocking and as the catalyst for the covalent bond forming reaction that captures the interlocked structure, has several advantages in comparison with traditional ‘passive template’ approaches. In contrast with passive template approaches the active template strategy is more efficient, completing the assembly of the interlocked structure in one step instead of two and in some cases requiring only a substoichiometric amount of metal template. In addition, fewer permanent recognition sites are required and in certain cases the active template reaction can shed light on mechanistic details of related metalcatalyzed processes and act as a conduit for reaction discovery. This Thesis will discuss the expansion of this new methodology in two main directions: firstly, exploration of new active metal template reactions, specifically the application of a novel Ni catalyzed sp3–sp3 C–C bond forming reaction, and secondly, the application of previously developed active template reactions to the synthesis of agrochemical-based [2]rotaxanes and other architectures, macrobicyclic [3]rotaxanes, [2]catenanes and a trefoil knot.
URI
http://hdl.handle.net/1842/4786
Collections
  • Chemistry thesis and dissertation collection

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page

 

 

All of ERACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisors
LoginRegister

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page