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Mitochondrial metabolism in livestock Trypanosomes: acetate production in Trypanosoma congolense
(The University of Edinburgh, 2022-08-01)African Animal Trypanosomiasis (AAT) is a debilitating disease affecting livestock in sub-Saharan Africa. AAT is caused by protozoan parasites of the genus Trypanosoma, with T. congolense being the species primarily ... -
Distributions of RNA polymerase and transcript numbers in models of gene expression describing the mRNA life-cycle
(The University of Edinburgh, 2022-07-29)Transcription, the production of RNA from a gene, is an inherently stochastic process, as recent experiments have firmly established. This stochasticity makes the modelling of genetic networks highly challenging. Recent ... -
Molecular and functional characterisation of an extracellular Argonaute protein secreted by a gastrointestinal nematode
(The University of Edinburgh, 2022-07-29)Parasites manipulate their hosts to promote infection by secreting bioactive molecules including proteins, lipids and RNAs. Helminths (parasitic worms) secrete a plethora of such molecules possessing immunogenic and ... -
Use of on-line metabolomics for bioprocess monitoring
(The University of Edinburgh, 2022-06-27)Biotechnology has the potential to play a key role in the transition from an economy based on non-renewable fossil fuels to a greener economy in which renewable feedstocks can be used to generate a wide range of products. ... -
Metataxonomic analysis of a novel anaerobic digester and engineering of isolated bacteria
(The University of Edinburgh, 2022-06-24)Biomolecular tools such as metataxonomic and metagenomic DNA sequencing approaches have facilitated our detailed understanding of the microbiology of anaerobic digestion (AD) systems in recent years. However, most studies ... -
Design and characterisation of Novel synthetic biology tools in cyanobacterial model species
(The University of Edinburgh, 2022-06-24)Cyanobacteria are a diverse phylum of prokaryotes capable of conducting oxygenic photosynthesis. They can efficiently harvest CO2 as a carbon source and transform it into sugars and complex molecules using sunlight, water, ... -
Comparative analysis of the function and regulation of the ZOU/ICE protein complex in Arabidopsis thaliana and Marchantia polymorpha
(The University of Edinburgh, 2022-06-23)In angiosperms, the development of the seed and the accumulation of reserves require the establishment of close communication between the embryo and the endosperm. In Arabidopsis thaliana, this coordination is regulated ... -
Cohesin loading and its roles in genome organisation in Schizosaccharomyces pombe
(The University of Edinburgh, 2022-06-23)The organisation of DNA varies throughout the cell cycle in a tightly regulated manner. This ranges from the formation of high order structures, during the condensing of chromosomes into sister chromatids in mitosis and ... -
Using locus-specific proteomics to investigate heterochromatin in Trypanosoma brucei
(The University of Edinburgh, 2022-06-23)The eukaryotic nucleus is classically divided into two broad categories: gene-poor heterochromatin and gene-rich euchromatin. In most model eukaryotes, heterochromatin is epigenetically defined by histone H3 lysine 9 ... -
From epidemics to pandemics: elucidating the dynamics of Ebola Virus and SARS-CoV-2
(The University of Edinburgh, 2022-06-22)The advent of large-scale viral genomic sequencing has provided a rich source of data to explore the dynamics of infectious disease epidemics. In combination with the field of phylodynamics, which allows the inference of ... -
Impact of mixed species infection on trypanosome virulence and transmission
(The University of Edinburgh, 2022-06-22)Animal African trypanosomes are protozoan parasites that cause nagana, a devastating disease of livestock in sub-Saharan Africa. It is well documented that strains of one causative agent, Trypanosoma congolense (subtype: ... -
Early signals of parasitism expressed through changes in host activity and social behaviour
(The University of Edinburgh, 2022-06-22)Parasites are ubiquitous in the environment and can profoundly impact the health and welfare of their hosts. Infected animals will often exhibit an array of behavioural responses that are termed sickness behaviours. By ... -
Role of Spo13 and Cdc5 in the establishment of sister kinetochore mono-orientation
(The University of Edinburgh, 2022-06-17)Meiosis is a type of cell division that leads to the creation of gametes. Unlike mitosis, which produces exact copies of the mother cell, the aim of meiosis is to halve the cell’s chromosomal content. To achieve this, the ... -
Self-assembling protein structures for novel applications in synthetic biology
(The University of Edinburgh, 2022-06-14)Self-assembling protein tools are highly desirable in the field of synthetic biology. They enable the creation of new macromolecular structures for novel applications, by providing users with the ability to ‘build’ with ... -
Role of C19ORF84H in MIWI2-mediated silencing of retrotransposons in the male germline
(The University of Edinburgh, 2022-06-13)Activity of transposable elements is regulated by DNA methylation. In mice, PIWI proteins MILI (MIWI-like) and MIWI2 (mouse piwi 2, also known as PIWIL4) are central to this process in the developing male germline. In that ... -
Characterisation of the enzymatic degradation of lignin
(The University of Edinburgh, 2022-06-10)Lignin is one of the most abundant and diverse biopolymers on the planet, comprising approximately one third of all woody plant matter. This complex, non-repeating, heteroaromatic polymeric structure provides endless ... -
Drastic times call for drastic measures: how timing affects host-parasite interactions
(The University of Edinburgh, 2022-06-08)Earth’s daily rotation causes predictable cycles of day and night, which all life has evolved to cope with. Circadian clocks (i.e. daily, biological timekeepers) are ubiquitous and allow organisms to schedule activities, ... -
Dissecting the role of HB-EGF in the shaping of CD4+ T cell immune responses
(The University of Edinburgh, 2022-06-07)CD4+ T cells critically contribute to host protection against infections but can also participate in the development of autoimmune diseases. Correct differentiation of naïve CD4+ T cells into effector subtypes is ... -
Immune regulation of disease tolerance and immune priming in Drosophila
(The University of Edinburgh, 2022-05-26)To regain health following infection, hosts must not only identify and eliminate the source of infection, but also be able to reduce the resulting tissue damage in order to tolerate immunopathology. Compared to the mechanisms ... -
Molecular basis for the assembly and centromere targeting of the Mis18 complex: a key regulator of centromere inheritance
(The University of Edinburgh, 2019-07-06)[No Deposit Agreement]
