Biological Sciences, School of
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Model reduction, mechanistic modelling and transience in models of stochastic chemical kinetics
(The University of Edinburgh, 2022-11-28)Now, it is long known that gene expression and chemical kinetics are subject to random fluctuations. These lead to deviations from deterministic models that do not account for the random nature of biochemical kinetics. ... -
Investigating the role of RNAi and epigenetic modifications in the basidiomycetes yeast Cryptococcus deneoformans
(The University of Edinburgh, 2022-11-25)The basidiomycete yeasts from the Cryptococcus neoformans/gattii species complex are major fungal pathogens and are particularly prevalent in the developing world. The species within the complex are rapidly evolving, ... -
Investigating the redundancy and specificity of YTHDF proteins
(The University of Edinburgh, 2022-11-24)N6-methyladenosine (m6A) is the most abundant internal messenger RNA (mRNA) modification. It affects nearly every aspect of mRNA metabolism such as splicing, transport and decay. m6A is a dynamic modification: a “writer” ... -
Mitochondrial dysfunction triggers distinct defects in meiotic chromatin arrangements
(The University of Edinburgh, 2022-11-18)The accurate transmission of genetic material in the germline is of vital importance to the offspring since the entire organism is affected. It is therefore critical that chromosomes are faithfully distributed during ... -
Towards a synthetic biology platform for the production of in vitro plant biomass
(The University of Edinburgh, 2022-11-16)To meet climatic targets, we require an urgent shift from the petroleum industry, alongside concerted rewilding efforts to sustain vital natural carbon sinks and biodiversity. Sourcing materials and fuels from plants ... -
Synthetic biology approach to engineer novel commercial variants of cyanobacterial pigment proteins
(The University of Edinburgh, 2022-11-26)Phycocyanin (PC) is a high-value blue pigment protein obtained from cyanobacteria and red algae. Inside the cell it is mainly responsible for light absorption at 620 nm as part of the light harvesting phycobilisome (PBS) ... -
Single cell analysis provides insight into haematopoietic differentiation of human embryonic stem cells
(The University of Edinburgh, 2022-10-19)One of the challenges in regenerative medicine remains generating functional haematopoietic stem cells (HSCs) of clinical quantity. Utilizing data from single cell RNA sequencing (scRNA-seq) of human embryonic stem ... -
Circadian magnesium transport in eukaryotic cells
(The University of Edinburgh, 2022-10-18)Circadian clocks have arisen in most eukaryotes and some prokaryotes to anticipate the rhythmic environmental changes imposed by Earth’s daily rotation on itself. These daily timekeeping mechanisms provide a competitive ... -
Novel genome editing technique in Chlamydomonas reinhardtii and its underlying DNA repair pathway
(The University of Edinburgh, 2022-10-04)The green microalga Chlamydomonas reinhardtii is an important model organism, with potential industrial biotechnology applications, including potential for vaccine production (e.g., TransAlgae, Israel) and vegan protein ... -
Fruit softening: demonstration of in-vivo pectate lyase and rhamnogalacturonan lyase action
(The University of Edinburgh, 2022-09-29)The programmed softening that occurs during fruit development requires scission of wall and/or middle lamella polysaccharides, especially pectin. Proposed mechanisms include the action of cell-wall enzymes [e.g. pectate ... -
Mechanistic and functional insights into the human kinesin motor CENP-E in cell division
(The University of Edinburgh, 2022-09-26)During mitosis, chromosomes align at the spindle equator and biorient in order to equally distribute the genome into two daughter cells. A macromolecular protein complex, known as the kinetochore, facilitates the end-on ... -
Glycyrrhiza glabra cambial meristematic cells as a production platform for high value chemicals
(The University of Edinburgh, 2022-09-22)Plant secondary metabolites represent both a current and future source of diverse molecules with desirable pharmaceutical characteristics. Exploration and utilisation of these highly chiral Plant Natural Products (PNPs) ... -
IgE-based cancer immunotherapy
(The University of Edinburgh, 2022-09-21)Anti-tumour effect of monoclonal antibodies (mAbs) can be achieved through different mechanisms in which both target engagement with Fab arm and Fc-mediated recruitment of effector immune cells play an important role. ... -
Plasmodium falciparum binding interactions with human brain endothelial cells
(The University of Edinburgh, 2016-11-29)Cerebral malaria is the most severe form of malaria and mostly affects children under 5 years causing impaired consciousness, coma and neurological disorders, with life-threatening consequences in affected individuals. ... -
Phylogenetics of Begonia section Gireoudia
(The University of Edinburgh, 2013-06-29)Begonia is one of the most species-rich angiosperm genera with c. 1500 species currently identified and a pantropical distribution. Although Begonia are predominantly found in ever wet rain forests, they can also be found ... -
Exploring the impact of interventions on the transmission dynamics of infectious diseases: antimicrobial resistant foodborne disease and COVID-19
(The University of Edinburgh, 2022-09-06)Antimicrobial resistance (AMR) and coronavirus disease 2019 (COVID-19) currently represent two of the most important threats to human health, with both AMR and COVID-19 resulting in millions of deaths worldwide and ... -
Genomic basis of sexually divergent traits in red deer (Cervus elaphus)
(The University of Edinburgh, 2022-08-31)Sexually selected traits show large variation and rapid evolution across the aniaml kingdom. The genetic variation underlying sexually selected traits is often maintained despite apparent directional selection, with proposed ... -
Regulation of RecBCD expression in Escherichia coli
(The University of Edinburgh, 2022-08-16)To preserve genome integrity, all living organisms have developed strategies to respond to chromosomal damage. One such response is the repair of double-strand breaks (DSBs), one of the most toxic forms of DNA damage. ... -
Mitochondrial metabolism in livestock Trypanosomes: acetate production in Trypanosoma congolense
(The University of Edinburgh, 2022-08-01)African Animal Trypanosomiasis (AAT) is a debilitating disease affecting livestock in sub-Saharan Africa. AAT is caused by protozoan parasites of the genus Trypanosoma, with T. congolense being the species primarily ... -
Distributions of RNA polymerase and transcript numbers in models of gene expression describing the mRNA life-cycle
(The University of Edinburgh, 2022-07-29)Transcription, the production of RNA from a gene, is an inherently stochastic process, as recent experiments have firmly established. This stochasticity makes the modelling of genetic networks highly challenging. Recent ...
