Biological Sciences, School of: Recent submissions
Now showing items 21-40 of 4045
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Glycyrrhiza glabra cambial meristematic cells as a production platform for high value chemicals
(The University of Edinburgh, 2022-09-22)Plant secondary metabolites represent both a current and future source of diverse molecules with desirable pharmaceutical characteristics. Exploration and utilisation of these highly chiral Plant Natural Products (PNPs) ... -
IgE-based cancer immunotherapy
(The University of Edinburgh, 2022-09-21)Anti-tumour effect of monoclonal antibodies (mAbs) can be achieved through different mechanisms in which both target engagement with Fab arm and Fc-mediated recruitment of effector immune cells play an important role. ... -
Plasmodium falciparum binding interactions with human brain endothelial cells
(The University of Edinburgh, 2016-11-29)Cerebral malaria is the most severe form of malaria and mostly affects children under 5 years causing impaired consciousness, coma and neurological disorders, with life-threatening consequences in affected individuals. ... -
Phylogenetics of Begonia section Gireoudia
(The University of Edinburgh, 2013-06-29)Begonia is one of the most species-rich angiosperm genera with c. 1500 species currently identified and a pantropical distribution. Although Begonia are predominantly found in ever wet rain forests, they can also be found ... -
Exploring the impact of interventions on the transmission dynamics of infectious diseases: antimicrobial resistant foodborne disease and COVID-19
(The University of Edinburgh, 2022-09-06)Antimicrobial resistance (AMR) and coronavirus disease 2019 (COVID-19) currently represent two of the most important threats to human health, with both AMR and COVID-19 resulting in millions of deaths worldwide and ... -
Genomic basis of sexually divergent traits in red deer (Cervus elaphus)
(The University of Edinburgh, 2022-08-31)Sexually selected traits show large variation and rapid evolution across the aniaml kingdom. The genetic variation underlying sexually selected traits is often maintained despite apparent directional selection, with proposed ... -
Regulation of RecBCD expression in Escherichia coli
(The University of Edinburgh, 2022-08-16)To preserve genome integrity, all living organisms have developed strategies to respond to chromosomal damage. One such response is the repair of double-strand breaks (DSBs), one of the most toxic forms of DNA damage. ... -
Mitochondrial metabolism in livestock Trypanosomes: acetate production in Trypanosoma congolense
(The University of Edinburgh, 2022-08-01)African Animal Trypanosomiasis (AAT) is a debilitating disease affecting livestock in sub-Saharan Africa. AAT is caused by protozoan parasites of the genus Trypanosoma, with T. congolense being the species primarily ... -
Distributions of RNA polymerase and transcript numbers in models of gene expression describing the mRNA life-cycle
(The University of Edinburgh, 2022-07-29)Transcription, the production of RNA from a gene, is an inherently stochastic process, as recent experiments have firmly established. This stochasticity makes the modelling of genetic networks highly challenging. Recent ... -
Molecular and functional characterisation of an extracellular Argonaute protein secreted by a gastrointestinal nematode
(The University of Edinburgh, 2022-07-29)Parasites manipulate their hosts to promote infection by secreting bioactive molecules including proteins, lipids and RNAs. Helminths (parasitic worms) secrete a plethora of such molecules possessing immunogenic and ... -
Use of on-line metabolomics for bioprocess monitoring
(The University of Edinburgh, 2022-06-27)Biotechnology has the potential to play a key role in the transition from an economy based on non-renewable fossil fuels to a greener economy in which renewable feedstocks can be used to generate a wide range of products. ... -
Metataxonomic analysis of a novel anaerobic digester and engineering of isolated bacteria
(The University of Edinburgh, 2022-06-24)Biomolecular tools such as metataxonomic and metagenomic DNA sequencing approaches have facilitated our detailed understanding of the microbiology of anaerobic digestion (AD) systems in recent years. However, most studies ... -
Design and characterisation of Novel synthetic biology tools in cyanobacterial model species
(The University of Edinburgh, 2022-06-24)Cyanobacteria are a diverse phylum of prokaryotes capable of conducting oxygenic photosynthesis. They can efficiently harvest CO2 as a carbon source and transform it into sugars and complex molecules using sunlight, water, ... -
Comparative analysis of the function and regulation of the ZOU/ICE protein complex in Arabidopsis thaliana and Marchantia polymorpha
(The University of Edinburgh, 2022-06-23)In angiosperms, the development of the seed and the accumulation of reserves require the establishment of close communication between the embryo and the endosperm. In Arabidopsis thaliana, this coordination is regulated ... -
Cohesin loading and its roles in genome organisation in Schizosaccharomyces pombe
(The University of Edinburgh, 2022-06-23)The organisation of DNA varies throughout the cell cycle in a tightly regulated manner. This ranges from the formation of high order structures, during the condensing of chromosomes into sister chromatids in mitosis and ... -
Using locus-specific proteomics to investigate heterochromatin in Trypanosoma brucei
(The University of Edinburgh, 2022-06-23)The eukaryotic nucleus is classically divided into two broad categories: gene-poor heterochromatin and gene-rich euchromatin. In most model eukaryotes, heterochromatin is epigenetically defined by histone H3 lysine 9 ... -
From epidemics to pandemics: elucidating the dynamics of Ebola Virus and SARS-CoV-2
(The University of Edinburgh, 2022-06-22)The advent of large-scale viral genomic sequencing has provided a rich source of data to explore the dynamics of infectious disease epidemics. In combination with the field of phylodynamics, which allows the inference of ... -
Impact of mixed species infection on trypanosome virulence and transmission
(The University of Edinburgh, 2022-06-22)Animal African trypanosomes are protozoan parasites that cause nagana, a devastating disease of livestock in sub-Saharan Africa. It is well documented that strains of one causative agent, Trypanosoma congolense (subtype: ... -
Early signals of parasitism expressed through changes in host activity and social behaviour
(The University of Edinburgh, 2022-06-22)Parasites are ubiquitous in the environment and can profoundly impact the health and welfare of their hosts. Infected animals will often exhibit an array of behavioural responses that are termed sickness behaviours. By ... -
Role of Spo13 and Cdc5 in the establishment of sister kinetochore mono-orientation
(The University of Edinburgh, 2022-06-17)Meiosis is a type of cell division that leads to the creation of gametes. Unlike mitosis, which produces exact copies of the mother cell, the aim of meiosis is to halve the cell’s chromosomal content. To achieve this, the ...
