Biological Sciences, School of: Recent submissions
Now showing items 61-80 of 4063
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Role of C19ORF84H in MIWI2-mediated silencing of retrotransposons in the male germline
(The University of Edinburgh, 2022-06-13)Activity of transposable elements is regulated by DNA methylation. In mice, PIWI proteins MILI (MIWI-like) and MIWI2 (mouse piwi 2, also known as PIWIL4) are central to this process in the developing male germline. In that ... -
Characterisation of the enzymatic degradation of lignin
(The University of Edinburgh, 2022-06-10)Lignin is one of the most abundant and diverse biopolymers on the planet, comprising approximately one third of all woody plant matter. This complex, non-repeating, heteroaromatic polymeric structure provides endless ... -
Drastic times call for drastic measures: how timing affects host-parasite interactions
(The University of Edinburgh, 2022-06-08)Earth’s daily rotation causes predictable cycles of day and night, which all life has evolved to cope with. Circadian clocks (i.e. daily, biological timekeepers) are ubiquitous and allow organisms to schedule activities, ... -
Dissecting the role of HB-EGF in the shaping of CD4+ T cell immune responses
(The University of Edinburgh, 2022-06-07)CD4+ T cells critically contribute to host protection against infections but can also participate in the development of autoimmune diseases. Correct differentiation of naïve CD4+ T cells into effector subtypes is ... -
Immune regulation of disease tolerance and immune priming in Drosophila
(The University of Edinburgh, 2022-05-26)To regain health following infection, hosts must not only identify and eliminate the source of infection, but also be able to reduce the resulting tissue damage in order to tolerate immunopathology. Compared to the mechanisms ... -
Critical survey of the literature relating to lodging in cereals
(The University of Edinburgh, 1957)So it has been decided on the basis of an intensive review of the literature in relation to the problems of lodging, assess the progress made towards solving the problem. The whole has been divided into four main sections: ... -
Investigation into the effect of physical soil conditions in the seed bed on the emergence of spring oats
(The University of Edinburgh, 1959)The investigation arose from the observation made durlng advisory work that poor establishment occurred in Spring Oats the cause of which could only be attributed to the physical condition of the seed bed. Other possible ... -
Effect of nitrogen on the growth, development and yield of winter wheat
(The University of Edinburgh, 1960)In a split-plot experiment two levels each of P. and K and three levels of 8» were applied with the seed to winter sown wheat. Observations made on the growth of the crop showed? (a) No significant effect of N. P. and ... -
Environmental change impacts on ovine gastrointestinal parasitism
(The University of Edinburgh, 2019-07-06)[No Deposit Agreement] -
Analysis of released peptidases and their role in the transmission biology of African trypanosomes
(The University of Edinburgh, 2022-07-06)The protozoan parasite, Trypanosoma brucei causes devastating diseases in both humans and animals in sub-Saharan Africa. They live extracellularly and undergo a complex life cycle involving the mammalian host and the ... -
Nuclear spatial organization influences centromere identity
(The University of Edinburgh, 2022-04-13)Centromeres are specialized chromosomal domains that provide the attachment site for spindle microtubules emanating from opposite spindle pole bodies (SPBs; centrosome equivalent). Centromere identity is epigenetically ... -
Evolutionary ecology of biological rhythms in malaria parasites
(The University of Edinburgh, 2022-04-11)Biological rhythms are a ubiquitous feature of life and are assumed to allow organisms coordinate their activities with daily rhythms in the abiotic environment resulting from the rotation of the Earth every 24 hours. ... -
Struggling to keep the batteries charged: energy metabolism as a drug target in kinetoplastid parasites
(The University of Edinburgh, 2022-04-11)The kinetoplastid parasites Trypanosoma brucei, T. cruzi, and Leishmania spp. are responsible for a variety of human and animal diseases including human African trypanosomiasis (HAT), Chagas disease, the leishmaniasis, ... -
Decoding malaria T-cell responses using adaptive immune receptor repertoire sequencing
(The University of Edinburgh, 2022-04-04)Malaria continues to be a serious public health problem in many parts of the world, and progress in reducing the global malaria burden has stalled in recent years. Despite decades of research, current vaccine candidates ... -
Effect of environmental factors on inter-individual differences in Engystomops pustulosus and Xenopus laevis tadpole behaviour
(The University of Edinburgh, 2022-03-22)Inter-individual differences in behaviour contribute to the raw material on which natural selection can act and have important ecological and evolutionary consequences for a population. Behaviour can vary at the among and ... -
Computational analysis of single-cell dynamics: protein localisation, cell cycle, and metabolic adaptation
(The University of Edinburgh, 2022-03-22)Cells need to be able to adapt quickly to changes in nutrient availability in their environment in order to survive. Budding yeasts constitute a convenient model to study how eukaryotic cells respond to sudden environmental ... -
Genomic epidemiology of SARS-CoV-2: from outbreak investigations, to national and international surveillance efforts
(The University of Edinburgh, 2022-03-18)The response of the global genomics community to the SARS-CoV-2 pandemic has been unprecedented. At time of writing there are more than 3.7 million SARS-CoV-2 genome sequences shared publicly on GISAID (www.gisaid.org). ... -
Understanding interactions between Ramularia collo-cygni and barley leaf physiology to target improvements in host resistance and disease control strategy
(The University of Edinburgh, 2022-03-14)Ramularia Leaf Spot (RLS) is an increasingly problematic disease of barley. Control options are limited as the causal fungus, Ramularia collo-cygni, has developed resistance to several of the major fungicide groups. ... -
Role of thioredoxin isoforms in plant immunity
(The University of Edinburgh, 2022-03-14)Post-translational protein modifications (PTM) are key mechanisms to increase proteomic complexity and functional diversity to regulate crucial cellular processes precisely. The plant immune system comprises complex ... -
Understanding phytochrome regulation of plant growth and carbon resource management in Arabidopsis Thaliana
(The University of Edinburgh, 2022-03-14)Plantshave the ability to monitor fluctuations in their light environment constantlyand actively adjust their metabolism to cope with variations in light andcarbon (C) resource availability. Phytochromes (phys), red and ...
