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dc.contributor.authorRead, Nick D
dc.contributor.authoret al
dc.coverage.spatial10en
dc.date.accessioned2005-02-09T17:38:48Z
dc.date.available2005-02-09T17:38:48Z
dc.date.issued2003-04-24
dc.identifier.citationGalagan JE et al, NATURE, 422 (6934): 859-868 APR 24 2003en
dc.identifier.uriwww.nature.com/nature
dc.identifier.urihttp://hdl.handle.net/1842/696
dc.description.abstractNeurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca21 signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP). Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.en
dc.format.extent656157 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectgenome sequenceen
dc.subjectfilamentous fungusen
dc.subjectNeurospora crassaen
dc.titleThe genome sequence of the filamentous fungus Neurospora crassaen
dc.typeArticleen


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