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dc.contributor.authorGandon, Sylvain
dc.contributor.authorMackinnon, Margaret J
dc.contributor.authorNee, Sean
dc.contributor.authorRead, Andrew F
dc.coverage.spatial6en
dc.date.accessioned2005-02-22T13:01:19Z
dc.date.available2005-02-22T13:01:19Z
dc.date.issued2001-12-13
dc.identifier.citationImperfect vaccines and the evolution of pathogen virulence Gandon S, Mackinnon MJ, Nee S, Read AF NATURE 414 (6865): 751-756 DEC 13 2001en
dc.identifier.uridoi:10.1038/414751a
dc.identifier.urihttp://www.nature.com/nature
dc.identifier.urihttp://hdl.handle.net/1842/711
dc.description.abstractVaccines rarely provide full protection from disease. Nevertheless, partially effective (imperfect) vaccines may be used to protect both individuals and whole populations.We studied the potential impact of different types of imperfect vaccines on the evolution of pathogen virulence (induced host mortality) and the consequences for public health. Here we show that vaccines designed to reduce pathogen growth rate and/or toxicity diminish selection against virulent pathogens. The subsequent evolution leads to higher levels of intrinsic virulence and hence to more severe disease in unvaccinated individuals. This evolution can erode any population-wide benefits such that overall mortality rates are unaffected, or even increase, with the level of vaccination coverage. In contrast, infection-blocking vaccines induce no such effects, and can even select for lower virulence. These findings have policy implications for the development and use of vaccines that are not expected to provide full immunity, such as candidate vaccines for malaria.en
dc.format.extent183524 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherNature Publishing Groupen
dc.subjectVaccinesen
dc.subjectpathogenen
dc.subjectvirulenceen
dc.subjectmalariaen
dc.titleImperfect vaccines and the evolution of pathogen virulenceen
dc.typeArticleen


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