Loss of Dicer fowls up centromeres
View/ Open
Date
08/2004Author
White, Sharon A
Allshire, Robin C
Metadata
Abstract
Centromeres, specialized regions on chromosomes, are essential for accurate chromosome segregation during cell
division. In fission yeast, the RNA interference machinery has a pivotal function in the assembly of centromeric
heterochromatin, which mediates sister centromere cohesion. Studies in vertebrate cells now suggest that many
aspects of this process are conserved.