Chemistry, School of
The School of Chemistry at the University of Edinburgh is the top rated for teaching and research in Scotland. In the 2008 Research Assessment Exercise EaStCHEM is 4th in the GPA metric and first when staff volume is factored in (the power ranking), sitting above Oxford and Cambridge.
The Universities of Edinburgh and St Andrews have formed EaStCHEM, which is the leading Chemistry research school in Scotland. Through continued collaboration between the two Universities EaStCHEM will become a driving force in a number of key research areas. EaStCHEM is also part of ScotCHEM, which strengthens links between the major Schools of Chemistry in Scottish Universities.
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Synthesis, structural and magnetic properties of some transition metal oxides
(The University of Edinburgh, 2020-06-25)The thesis compiles the synthesis and study of several new materials in the perovskite and corundum families. These transition-metal oxide materials have been structurally characterised and their physical properties have ... -
Design and synthesis of novel polymers of intrinsic microporosity for gas separations
(The University of Edinburgh, 2020-06-25)Polymers of Intrinsic Microporosity (PIMs) are a new class of microporous material combining excellent solution processability with great structural diversity. The microporosity of PIMs derives from the inefficient ... -
Improvement of modelling human exposure to NO₂ in cities in China: the case of Guangzhou
(The University of Edinburgh, 2020-06-25)Nitrogen dioxide (NO₂) is an air pollutant identified as a public health concern. Exposure to NO₃ is associated with a number of adverse respiratory health effects, and ultimately with premature mortality. It also contributes ... -
Development of an information theory based computational framework for the analysis of molecular dynamics simulations of proteins under allosteric regulation
(The University of Edinburgh, 2020-06-25)Allosteric signalling was first discovered over 50 years ago, yet the underlying molecular determinants are not yet completely understood. The ability to predict the activity of allosteric small molecules could have a huge ... -
Novel fluorescent probes for monitoring T cell localisation and activity
(The University of Edinburgh, 2020-03-19)Cancer is one of the deadliest diseases known to humanity. In the UK someone is diagnosed with cancer every two minutes. The associated mortality rates vary depending on the type of cancer but despite this being such ... -
Palladium catalysts for cancer imaging
(The University of Edinburgh, 2020-03-19)Lung cancer is one of the most devastating diseases with a 5-year survival rate of 17 %. The reason for this poor prognosis is that the disease is often detected at a late stages because of the reliance on low accuracy/low ... -
Development of a high-throughput drug screening platform for oligodendrocyte myelination (for progressive multiple sclerosis)
(The University of Edinburgh, 2020-03-20)Aim As part of the broad strategy in Edinburgh and beyond to discover new treatments for progressive Multiple Sclerosis (MS), the aims for my PhD project were: (1) to address the lack of an in vitro phenotypic drug ... -
Self-assembling block copolymers in the nucleation of hydroxyapatite
(The University of Edinburgh, 2020-06-25)Dental erosion is a pandemic affecting 3.6 billion people in the world. Over 95 % of enamel is composed of calcium hydroxyapatite (HAP). Enamel is acellular, and as a result of our lifestyle and daily wear and tear this ... -
Arrays of 3D polymer scaffolds for biomedical applications
(The University of Edinburgh, 2020-06-25)The field of functional biomaterials has seen huge progression with enormous efforts made to discover 3D scaffolds that support and promote tissue formation. Polymerbased 3D scaffolds are used extensively as a consequence ... -
SERS substrates for sensing in pathology and physiology
(The University of Edinburgh, 2020-06-25)Monitoring physiological parameters such as pH at the site of a disease are important in determining the health status in patients. Current approaches are based on the analysis of arterial blood to measure systemic ... -
High-pressure studies of energetic co-crystals
(The University of Edinburgh, 2020-06-25)Co-crystals have been widely explored in the field of energetic materials for more than a decade. Their ability to tune the physical, chemical and energetic properties of a material without the need to synthesise new ... -
Development of sustainable catalytic methods for organic synthesis
(The University of Edinburgh, 2020-06-25)This thesis covers two separate projects, but both of which can be linked by the overall aim to develop sustainable catalytic methodology for use in organic synthesis. A concerted effort has been made to move away from ... -
Robust capsules for biomedical applications
(The University of Edinburgh, 2020-06-25)Metallosupramolecular capsules represent a facile route to three-dimensional structures that possess a central cavity. The synthetic accessibility is provided by self-assembly, which allows carefully designed components ... -
Spectroscopic analysis of apoptotic tumour cell-derived extracellular vesicles
(The University of Edinburgh, 2019-08-31)Extracellular vesicles (EVs) are small, membrane delimited particles which are released from cells of all types and disease status. When EVs were first discovered they were thought to be a mechanism to remove waste from ... -
Morpholino oligonucleotides in responsive hydrogels for microRNA sensing
(The University of Edinburgh, 2020-06-25)In recent years, microRNA (miRNA) has garnered a high level of interest in the field of biosensor development. MiRNA are a class of small, circulating RNA sequences that are essential for healthy control of protein ... -
Hypervalent iodine(III) oxidants in gold catalysis
(The University of Edinburgh, 2020-06-25)Hypervalent iodine oxidants have been used extensively in oxidative metal catalysis, especially in gold catalysis, where the redox potential of gold(I) to gold(III) is large. The reoxidation of gold(I) within an intramolecular ... -
Development of earth-abundant metal catalysts for carbon-boron and carbon-carbon bond forming reactions
(The University of Edinburgh, 2020-06-25)We have developed a Markovnikov-selective cobalt-catalysed hydroboration of alkenes with pinacolborane at ambient temperature, using a bench-stable bipyridyl-oxazoline catalyst tBuBPOCoCl2 and NaOtBu as the in situ ... -
Functionalisable cyclopolymers by ring-closing metathesis
(The University of Edinburgh, 2020-02-06)Post‐polymerisation modification of polymers is extremely beneficial in terms of designing brand new synthetic pathways toward functional complex polymers. While many chemical groups could provide a platform for chemical ... -
Developing a spectroscopic technique for assessing liver health
(The University of Edinburgh, 2020-02-10)As our largest internal organ, the liver is responsible for the breakdown of toxic compounds, synthesis of multiple hormones and also plays a vital role in metabolism. However, liver disease is the only major cause of ... -
Molecular dynamics study of the structure of functionalised copolymers
(The University of Edinburgh, 2020-02-10)Polymers can be decorated with functional groups (FGs) to confer specific and tuneable properties to the molecules. By varying the chemical architecture, concentration, and distribution of the FGs on the polymer, it is ...
