Chemistry, School of: Recent submissions
Now showing items 1-20 of 2221
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Heavier group 13 based frustrated Lewis pairs for catalytic C–H borylation
(The University of Edinburgh, 2021-07-31)Research into catalysis has always been of great interest to both academic researchers and in industry, due to the great utility that catalysts possess. In particular, research into catalysts that are based on more ... -
Effects of high pressure on the electronic spectra and crystal structure of molecular materials
(The University of Edinburgh, 2021-07-31)The fluorescence of solid-state molecular materials is a field of growing research interest, stimulated by technological applications, such as organic light-emitting diodes and optical sensing. Investigation of the ... -
Arene activation and functionalisation by reducing complexes of uranium and iron
(The University of Edinburgh, 2021-07-31)The primary focus of the work described herein concerns the synthesis of uranium complexes and their reactivity towards small-molecules i.e. simple unsaturated kinetically inert compounds. Chapter 4 investigates the ... -
Implementation and impact of isotope depletion for improved protein mass spectrometry
(The University of Edinburgh, 2021-07-31)One of the fundamental challenges of high-resolution mass spectrometry (MS) analysis of protein occurs as the molecular weight increases. This is due to the increased chemical complexity of the protein analyte, as ... -
Imaging extracellular vesicles arising from apoptotic tumour cells for cancer diagnosis and monitoring
(The University of Edinburgh, 2021-07-31)As a large part of all health-related research is focused on cancer, and with several diagnostic and therapeutic procedures continuously emerging, the fact that this disease remains mostly uncured often seems overwhelming. ... -
Development of a novel imaging platform for the detection of apoptotic cells
(The University of Edinburgh, 2021-07-31)In the human body, billions of cells die every day, a cell death that is termed apoptosis. Clearance of these cells is crucial for the maintenance of homeostasis and dysregulation leads to inflammation and cancer. The ... -
Investigating the structure of encapsulin: encapsulated ferritin systems using mass spectrometry and electron microscopy
(The University of Edinburgh, 2020-11-30)Ferritins are ubiquitous proteins used to sequester and store iron in almost all life forms. In classical ferritins, iron is oxidised from Fe(II) to Fe(III) and then stored as a ferrihydrite mineral within a spherical ... -
Exploring biocatalysts for organic synthesis: Mechanism, promiscuity and engineering
(The University of Edinburgh, 2020-11-30)In recent years, enzymes, and their uses as biocatalysts for synthetic organic chemistry, have been positively disrupting the pharmaceutical and chemical industries. With the development of the third wave of biocatalysis ... -
Studies on the excited electronic states of fullerenes
(The University of Edinburgh, 2020-11-30)This work focused on investigating the excited electronic states of fullerenes. Due to their highly symmetric nature and elemental purity, fullerenes are ideal model systems for studying and understanding the excitation ... -
Investigating the recovery of rare earth elements by ionic liquids and bacteria
(The University of Edinburgh, 2020-11-30)The work presented in this thesis focuses on developing and understanding practices and reagents that can be more efficient at rare earth element (REE) recovery and separation than current industrial reagents and ... -
Enhanced Raman spectroscopy as a tool for the improvement of cervical cancer screening: a comparison of global and targeted approaches
(The University of Edinburgh, 2020-11-30)Half a million women worldwide are diagnosed with cervical cancer annually, with 87% of mortalities occurring in developing economies. HPV vaccination has reduced disease incidence significantly but must be supplemented ... -
Interpretation of the crystal structures of transition metal compounds and complexes
(The University of Edinburgh, 2020-11-30)The Cambridge Structural Database (CSD) contains over half a million structures containing transition metal compounds. The wealth of data available from these structures is enormous and the potential knowledge and insight ... -
Ultrafast photophysics of high-spin metal complexes
(The University of Edinburgh, 2020-11-30)Transition metal complexes (TMCs) show unusual optical, magnetic and chemical properties in comparison to purely organic molecules. These properties make them suitable for several applications. Organic light emitting ... -
Development of novel molecular tools for the characterisation of zebrafish renin
(The University of Edinburgh, 2020-11-30)The renin angiotensin system (RAS) is highly conserved across vertebrates. However, until recently it has not been extensively explored in zebrafish, an important model organism suitable for developmental studies, ... -
New oxidants for arylations with gold
(The University of Edinburgh, 2020-11-30)Gold as an element, has been known for tens of thousands of years, though only recently has the chemistry of gold complexes emerged as an important field for synthetic organic chemistry research. One significant challenge ... -
Development and application of low-cost monitoring approaches for atmospheric ammonia, acid gases and ammonium aerosols
(The University of Edinburgh, 2020-07-30)Ammonia (NH3) is the major alkaline gas in the atmosphere, with around 90 % of the total anthropogenic emissions in Europe coming from agriculture-related sources. Following emission to the atmosphere, the neutralisation ... -
Substituent effects on non-covalent interactions
(The University of Edinburgh, 2020-07-29)Non-covalent interactions play a vital role in biological and chemical systems, underpinning important processes such as ligand–receptor binding and protein structure. Substituent effects on these non-covalent interactions ... -
Investigation of the interactions between fluorescent base analogues and the natural DNA bases
(The University of Edinburgh, 2020-07-25)DNA and RNA are integral to all life on Earth, and yet their physical properties and behaviour in their native environment are still only imperfectly understood. Using fluorescent analogues of natural DNA bases (FBAs) ... -
Ultrafast Imaging of photochemical dynamics via x-ray scattering: connecting theory and experiments
(The University of Edinburgh, 2020-07-25)Although photochemical reactivity has been extensively studied, a clear picture of the underlying dynamics is largely missing predominantly because of the extremely short reaction times involved in these processes. ... -
Elemental and supramolecular diversity of nanoporous phthalocyanine crystals
(The University of Edinburgh, 2020-07-25)Phthalocyanines (Pcs) have a wide variety of applications as colorants, photodynamic therapeutics, photovoltaic materials, catalysts etc. Pcs tend to co-facially aggregate due to the π – π interactions between their ...
