Chemistry, School of: Recent submissions
Now showing items 1-20 of 2206
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Development of novel molecular tools for the characterisation of zebrafish renin
(The University of Edinburgh, 2020-11-30)The renin angiotensin system (RAS) is highly conserved across vertebrates. However, until recently it has not been extensively explored in zebrafish, an important model organism suitable for developmental studies, ... -
New oxidants for arylations with gold
(The University of Edinburgh, 2020-11-30)Gold as an element, has been known for tens of thousands of years, though only recently has the chemistry of gold complexes emerged as an important field for synthetic organic chemistry research. One significant challenge ... -
Development and application of low-cost monitoring approaches for atmospheric ammonia, acid gases and ammonium aerosols
(The University of Edinburgh, 2020-07-30)Ammonia (NH3) is the major alkaline gas in the atmosphere, with around 90 % of the total anthropogenic emissions in Europe coming from agriculture-related sources. Following emission to the atmosphere, the neutralisation ... -
Substituent effects on non-covalent interactions
(The University of Edinburgh, 2020-07-29)Non-covalent interactions play a vital role in biological and chemical systems, underpinning important processes such as ligand–receptor binding and protein structure. Substituent effects on these non-covalent interactions ... -
Investigation of the interactions between fluorescent base analogues and the natural DNA bases
(The University of Edinburgh, 2020-07-25)DNA and RNA are integral to all life on Earth, and yet their physical properties and behaviour in their native environment are still only imperfectly understood. Using fluorescent analogues of natural DNA bases (FBAs) ... -
Ultrafast Imaging of photochemical dynamics via x-ray scattering: connecting theory and experiments
(The University of Edinburgh, 2020-07-25)Although photochemical reactivity has been extensively studied, a clear picture of the underlying dynamics is largely missing predominantly because of the extremely short reaction times involved in these processes. ... -
Elemental and supramolecular diversity of nanoporous phthalocyanine crystals
(The University of Edinburgh, 2020-07-25)Phthalocyanines (Pcs) have a wide variety of applications as colorants, photodynamic therapeutics, photovoltaic materials, catalysts etc. Pcs tend to co-facially aggregate due to the π – π interactions between their ... -
Synthesis, structural and magnetic properties of some transition metal oxides
(The University of Edinburgh, 2020-06-25)The thesis compiles the synthesis and study of several new materials in the perovskite and corundum families. These transition-metal oxide materials have been structurally characterised and their physical properties have ... -
Design and synthesis of novel polymers of intrinsic microporosity for gas separations
(The University of Edinburgh, 2020-06-25)Polymers of Intrinsic Microporosity (PIMs) are a new class of microporous material combining excellent solution processability with great structural diversity. The microporosity of PIMs derives from the inefficient ... -
Improvement of modelling human exposure to NO₂ in cities in China: the case of Guangzhou
(The University of Edinburgh, 2020-06-25)Nitrogen dioxide (NO₂) is an air pollutant identified as a public health concern. Exposure to NO₃ is associated with a number of adverse respiratory health effects, and ultimately with premature mortality. It also contributes ... -
Development of an information theory based computational framework for the analysis of molecular dynamics simulations of proteins under allosteric regulation
(The University of Edinburgh, 2020-06-25)Allosteric signalling was first discovered over 50 years ago, yet the underlying molecular determinants are not yet completely understood. The ability to predict the activity of allosteric small molecules could have a huge ... -
Novel fluorescent probes for monitoring T cell localisation and activity
(The University of Edinburgh, 2020-03-19)Cancer is one of the deadliest diseases known to humanity. In the UK someone is diagnosed with cancer every two minutes. The associated mortality rates vary depending on the type of cancer but despite this being such ... -
Palladium catalysts for cancer imaging
(The University of Edinburgh, 2020-03-19)Lung cancer is one of the most devastating diseases with a 5-year survival rate of 17 %. The reason for this poor prognosis is that the disease is often detected at a late stages because of the reliance on low accuracy/low ... -
Development of a high-throughput drug screening platform for oligodendrocyte myelination (for progressive multiple sclerosis)
(The University of Edinburgh, 2020-03-20)Aim As part of the broad strategy in Edinburgh and beyond to discover new treatments for progressive Multiple Sclerosis (MS), the aims for my PhD project were: (1) to address the lack of an in vitro phenotypic drug ... -
Self-assembling block copolymers in the nucleation of hydroxyapatite
(The University of Edinburgh, 2020-06-25)Dental erosion is a pandemic affecting 3.6 billion people in the world. Over 95 % of enamel is composed of calcium hydroxyapatite (HAP). Enamel is acellular, and as a result of our lifestyle and daily wear and tear this ... -
Arrays of 3D polymer scaffolds for biomedical applications
(The University of Edinburgh, 2020-06-25)The field of functional biomaterials has seen huge progression with enormous efforts made to discover 3D scaffolds that support and promote tissue formation. Polymerbased 3D scaffolds are used extensively as a consequence ... -
SERS substrates for sensing in pathology and physiology
(The University of Edinburgh, 2020-06-25)Monitoring physiological parameters such as pH at the site of a disease are important in determining the health status in patients. Current approaches are based on the analysis of arterial blood to measure systemic ... -
High-pressure studies of energetic co-crystals
(The University of Edinburgh, 2020-06-25)Co-crystals have been widely explored in the field of energetic materials for more than a decade. Their ability to tune the physical, chemical and energetic properties of a material without the need to synthesise new ... -
Development of sustainable catalytic methods for organic synthesis
(The University of Edinburgh, 2020-06-25)This thesis covers two separate projects, but both of which can be linked by the overall aim to develop sustainable catalytic methodology for use in organic synthesis. A concerted effort has been made to move away from ... -
Robust capsules for biomedical applications
(The University of Edinburgh, 2020-06-25)Metallosupramolecular capsules represent a facile route to three-dimensional structures that possess a central cavity. The synthetic accessibility is provided by self-assembly, which allows carefully designed components ...
