Edinburgh Research Archive logo

Edinburgh Research Archive

University of Edinburgh homecrest
View Item 
  •   ERA Home
  • Edinburgh Medical School
  • Edinburgh Medical School Publications
  • View Item
  •   ERA Home
  • Edinburgh Medical School
  • Edinburgh Medical School Publications
  • View Item
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cdk5 is essential for synaptic vesicle endocytosis

View/Open
ncb1020.pdf (2.620Mb)
Date
08/2003
Author
Tan, Timothy C
Valova, Valentina A
Malladi, Chandra S
Graham, Mark E
Berven, Leise A
Jupp, Orla J
Hansra, Gurdip
McClure, Sonya J
Sarcevic, Boris
Boadle, Ross A
Larsen, Martin R
Cousin, Michael A
Robinson, Phillip J
Metadata
Show full item record
Abstract
Synaptic vesicle endocytosis (SVE) is triggered by calcineurin-mediated dephosphorylation of the dephosphin proteins. SVE is maintained by the subsequent rephosphorylation of the dephosphins by unidentified protein kinases. Here, we show that cyclindependent kinase 5 (Cdk5) phosphorylates dynamin I on Ser 774 and Ser 778 in vitro, which are identical to its endogenous phosphorylation sites in vivo. Cdk5 antagonists and expression of dominant-negative Cdk5 block phosphorylation of dynamin I, but not of amphiphysin or AP180, in nerve terminals and inhibit SVE. Thus Cdk5 has an essential role in SVE and is the first dephosphin kinase identified in nerve terminals.
URI
doi:10.1038/ncb1020

http://www.nature.com/ncb/

http://hdl.handle.net/1842/758
Collections
  • Edinburgh Medical School Publications

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page

 

 

All of ERACommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisorsThis CollectionBy Issue DateAuthorsTitlesSubjectsPublication TypeSponsorSupervisors
LoginRegister

Library & University Collections HomeUniversity of Edinburgh Information Services Home
Privacy & Cookies | Takedown Policy | Accessibility | Contact
Privacy & Cookies
Takedown Policy
Accessibility
Contact
feed RSS Feeds

RSS Feed not available for this page