Royal (Dick) School of Veterinary Studies: Recent submissions
Now showing items 1-20 of 1005
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Gene editing for resistance to influenza A virus in swine
(The University of Edinburgh, 2022-11-25)Influenza A Virus (IAV) presents a major threat to human health and animal welfare. As pigs are susceptible to infection from avian and mammalian origin IAVs, they can be an intermediate host for onwards transmission ... -
Immunopathogenesis of Chlamydia abortus infections in vaccinated and non-vaccinated ewes
(The University of Edinburgh, 2022-11-16)Enzootic abortion of ewes (EAE) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. EAE is considered one of the most important causes of infectious abortion in sheep in many parts of the ... -
Investigation of the clinical safety and efficacy of lyophilized platelets in the treatment of bleeding associated with thrombocytopenia in dogs
(The University of Edinburgh, 2021-12-08)Introduction Platelets (thrombocytes) are an essential part of the mammalian haemostasis system. Platelets localise to sites of injury, adhere, activate and aggregate in a process termed primary haemostasis. Thrombocytopenia ... -
Impact of Atypical Porcine Pestivirus (APPV) in Great Britain
(The University of Edinburgh, 2022-09-28)Atypical porcine pestivirus (APPV) is a positive-sense ribonucleic acid (RNA) enveloped virus belonging to the Pestivirus genus, a group of viruses known for their high socio-economic impact. Since its discovery in 2015, ... -
Functional genomics in the regulation of the immune response
(The University of Edinburgh, 2022-09-02)Genetics contribute substantially to the ability of the immune system to respond appropriately to a challenge. Consequently, many infectious and inflammatory diseases have a heritable component. As genome-wide association ... -
Behavioural and physiological consequences of tooth resection in commercial piglets: implications for welfare
(The University of Edinburgh, 2022-06-30)BACKGROUND: In commercial farming the shortening of piglet needle teeth is a common but controversial and legally restricted practice due to its potential to induce pain and stress. However, very limited data on the long ... -
Post-transcriptional regulation of a micro-injection system
(The University of Edinburgh, 2022-06-29)Enterohaemorrhagic Escherichia coli (EHEC) is a food-borne pathogen associated with outbreaks of bloody diarrhoea and haemolytic uraemic syndrome in humans. It originates from asymptomatic carriage in cattle and other ... -
Movement, mobility and disease modelling in three epidemic contexts
(The University of Edinburgh, 2022-06-29)Infectious diseases have played a considerable role in shaping human history. Although their global burden has significantly decreased through the past centuries, they are still among the main causes of human death worldwide. ... -
Modelling short- and long-term resilience and efficiency of cattle production in Europe
(The University of Edinburgh, 2022-06-28)Efficiency is a long-standing objective of dairy cattle production systems. However, the expected impact of external stressors such as climate change means resilience may now be an increasingly important production goal. ... -
Investigating the role of persisting antigen in immunity against foot-and-mouth disease virus
(The University of Edinburgh, 2022-06-27)Foot-and-mouth disease (FMD) is one of the most economically important diseases of livestock, characterised by fever and blister like sores on the tongue and around the mouth and on the feet, resulting in a significantly ... -
Mechanisms underpinning chronic kidney disease-mineral and bone disorder
(The University of Edinburgh, 2022-06-17)Chronic kidney disease (CKD) is an irreversible systemic disease characterised by the gradual loss of kidney function over time. Patients with progressive CKD frequently encounter altered levels of circulating and bone-derived ... -
Horse welfare within Traveller/Gypsy communities; ethnic groups under-represented in horse welfare research
(The University of Edinburgh, 2022-06-16)Travellers/Gypsies are recognised ethnic groups in the UK and Ireland. Horses are significant to their lives, with horse ownership seen as a last link to their nomadic way of life. While horse welfare issues can be found ... -
DNA methylation as a determinant of organism size
(The University of Edinburgh, 2022-06-14)Microcephalic dwarfism (MD) represents a group of single gene disorders that are characterised by a severe reduction in head and body size. Over 40 genes have been identified as MD genes. A common feature of many of these ... -
Development of antibody therapeutic approaches for poultry diseases using avian influenza as a disease model
(The University of Edinburgh, 2022-06-08)One of the main threats to poultry is avian influenza virus (AIV), causing significant economic losses worldwide and threatening human populations due to its zoonotic potential. To reduce disease impact, vaccination of ... -
Investigating alternative AUG codon usage in avian influenza A virus segment 2
(The University of Edinburgh, 2022-06-07)Influenza A viruses (IAVs) have a segmented, negative sense RNA genome. PB1-F2 is an IAV accessory protein encoded by segment 2, in the +1 reading frame. Avian IAVs predominantly encode full length PB1-F2s, whereas ... -
Investigation of the associations between the gastrointestinal microbiome and animal host performance and health
(The University of Edinburgh, 2022-06-07)The projected human population growth drives a worldwide increased pressure to improve animal production systems from both the economic and environmental perspectives. Bovine ruminants are one of the most interesting ... -
Stress in equids undergoing veterinary care and the development of interventions that positively influence the horses' experience
(The University of Edinburgh, 2022-06-07)Veterinary care can be essential for maintaining the physical health of horses and yet the impact of veterinary care on a horse’s emotional state and how that influences their behavioural responses has not been ... -
Exploring sex differences in the response to tickling in juvenile Wistar rats
(The University of Edinburgh, 2022-06-07)Positive welfare is considered not simply the absence of suffering, but also the presence of positive experiences. ‘Tickling’ induces positive affective states in laboratory rats as evidenced by the production of 50 ... -
Refining and applying comparative proteomics workflows to uncover novel regulators of neuronal stability between childhood and adult-onset degenerative diseases
(The University of Edinburgh, 2022-06-07)Early structural, functional and molecular dysregulation in the synapse unites the majority of neurodegenerative conditions, including those without any current available therapeutic option. These similarities suggest ... -
Development of multi-parametric tests for the diagnosis of feline tuberculosis
(The University of Edinburgh, 2022-06-06)Mycobacterial infections cause a substantial burden of disease in both human and animal populations and continue to provide a challenge in terms of both their diagnosis and treatment. Feline mycobacterial infections ...
