ERA: Recent submissions
Now showing items 1-20 of 36824
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Sebastiano Serlio's architectural principles in Britain, 1600-1750
(The University of Edinburgh, 2021-07-31)This thesis examines the reception of the woodcut-illustrated architectural treatises and architectural mathematics of the Bolognese architect-painter Sebastiano Serlio (1475-1554) in Britain from the ‘Scientific ... -
Superconducting wireless power transfer for electric vehicles
(The University of Edinburgh, 2021-07-31)Electric vehicles (EVs) are an important pillar for the transition towards a cleaner and more sustainable future as renewable energy can penetrate into the transportation section and act as energy storage to cope with ... -
Numerical modelling of ground penetrating radar for optimization of the time-zero adjustment and complex refractive index model
(The University of Edinburgh, 2021-07-31)Time-zero adjustment or the true ground surface for Ground Penetrating Radar (GPR) applications is a very important aspect and an essential factor in order to carry out accurate shallow depth measurements. As the transmitted ... -
Optical fibre chemical sensors and biosensors based on fluorescent polymers
(The University of Edinburgh, 2021-07-31)Optical fibre-based pH sensors have been well explored and studied for physiological use since the development of the first optical fibre pH probe in 1980. However, the need for robust attachment of pH reporters onto ... -
Effects of stress on the microbial ruminal environment in beef cattle and its relationship to feed efficiency and methane emissions
(The University of Edinburgh, 2021-07-31)There is currently a poor understanding of the impact of chronic stress on the behaviour and physiology of beef cattle. In monogastrics, hormones released in response to stress can have deleterious effects on the balance ... -
Designing breeding programs in the genomic era
(The University of Edinburgh, 2021-07-31)Increasing the rate of genetic gain of breeding programs is one route to achieve sustainable increases in food production. Breeding has been responsible for ~50% of the increases in agricultural productivity over the ... -
Tissue-resident immune cells in health and disease: their heterogeneity and associated gene signatures
(The University of Edinburgh, 2021-07-31)The immune system is comprised of numerous cell types, molecules and pathways whose primary purpose is to regulate tissue homeostasis and protect an individual from disease. Researchers have tried to identify and characterise ... -
Monitoring the reproductive status of dairy cows using cow-side oestrus detection technologies
(The University of Edinburgh, 2021-07-31)Reproductive failure remains one of the main reasons for culling in dairy herds worldwide. Prolonged inter-calving periods occasioned by failure or delay in conceiving reduces the lifetime productivity of the cows and ... -
Are peptides from injected effector proteins of enterohaemorrhagic E. coli O157:H7 presented by MHC class I and does this lead to CD8-mediated killing of colonised bovine epithelial cells
(The University of Edinburgh, 2021-07-31)Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 can cause haemorrhagic diarrhoea and potentially fatal renal failure in humans. Ruminants are considered the primary reservoir for human infection, for which studying ... -
Novel mechanisms regulating the membrane recruitment of the ATG8 conjugation machinery
(The University of Edinburgh, 2021-07-31)Autophagy is a highly conserved eukaryotic process that maintains cell viability by targeting excess or damaged cytoplasmic material for lysosomal degradation. This process involves the generation of a double-membraned ... -
Breast cancer incidence and survival trends by molecular subtypes in Scotland
(The University of Edinburgh, 2021-07-31)Background: Breast cancer (BC) is the most common cancer among women and leading contributor to cancer mortality, hence constitutes a major public health issue worldwide. In Scotland, over 4,000 women are diagnosed ... -
Molecular and therapeutic stratification of endometrioid ovarian carcinoma
(The University of Edinburgh, 2021-07-31)Epithelial ovarian carcinomas (EOC) comprise five main histological subtypes, each displaying distinct pathological, molecular and clinical characteristics. Endometrioid ovarian carcinomas (EnOC) account for 10% of EOC ... -
Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
(The University of Edinburgh, 2021-07-31)I set out to investigate whether common germline variance associated with colorectal cancer (CRC) risk can influence the somatic mutational landscapes of CRC. Some Mendelian cancer syndromes, such as Lynch syndrome ... -
Reviewing people with Obstructive Sleep Apnoea Hypopnoea Syndrome: telehealth and templates
(The University of Edinburgh, 2021-07-31)Introduction Obstructive Sleep Apnoea Hypopnoea Syndrome (OSAHS) is estimated to affect one billion people globally, carrying a substantial risk of road traffic accidents due to daytime sleepiness with additional other ... -
Exploring how Japanese family physicians understand palliative care and identify patients for primary palliative care
(The University of Edinburgh, 2021-07-31)Background: Primary care clinicians have great potential to play a key role in providing palliative care in the community. However, difficulties in identifying patients for palliative care hinders progress. This problem ... -
New insights into probabilistic pattern formation of embryonic stem cells using agent-based modelling
(The University of Edinburgh, 2021-07-31)Embryonic stem cells (ESCs) hold great potential for developing future therapies for a wide range of diseases. However, the mechanisms of pattern formation during embryonic development remain poorly understood. ESCs in ... -
Allosteric regulation of the AAA+ superfamily protein reptin
(The University of Edinburgh, 2021-07-31)Reptin is a member of the AAA+ (adenosine triphosphatase associated with diverse cellular activities) protein superfamily with roles in many protein complexes and interactions which have been indicated in cancer including ... -
Role of IL6ST in endocrine sensitivity of breast cancer
(The University of Edinburgh, 2021-07-31)Breast cancer is the most common type and cause of cancer death in women. Oestrogen is a major growth stimulant of oestrogen receptor alpha (ERa) positive breast cancer and consequently, endocrine therapy which targets ... -
Role of perinatal inflammation in preterm brain injury
(The University of Edinburgh, 2021-07-31)Perinatal inflammation is associated with an increased risk of brain injury and neurodevelopmental impairment in preterm infants but the immune mediators driving this association are not well understood. This PhD thesis ... -
Manganese-enhanced magnetic resonance imaging of the myocardium
(The University of Edinburgh, 2021-07-31)Background Current clinical cardiac magnetic resonance imaging uses gadolinium contrast to detect myocardial pathology by characterising the extracellular space. Whilst a valuable clinical tool, gadolinium-based media ...
