ERA: Recent submissions
Now showing items 1-20 of 35548
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Examining the potential of rationally designed recombinant Infectious Bronchitis Virus as a vaccine against Infectious Bronchitis
(The University of Edinburgh, 2020-07-04)Infectious Bronchitis Virus (IBV) is a gammacoronavirus that is prevalent in poultry flocks worldwide. Infection results in Infectious Bronchitis (IB), an economically important disease characterised by snicking, rales, ... -
Standardisation of preclinical PET/CT protocols across multiple research centres
(The University of Edinburgh, 2020-06-27)Preclinical Positron Emission Tomography/Computed Tomography (PET/CT) is a well-established non-invasive imaging tool for studying disease development/progression, the development of novel radiotracers and pharmaceuticals ... -
Molecular characterisation of human prion amplification in cell-free systems and diagnostic applications
(The University of Edinburgh, 2020-06-27)Prion diseases are a group of fatal neurodegenerative diseases associated with proteopathy occurring in humans and other mammals. The mechanism of prion replication is thought to be based on the induced misfolding of the ... -
Scots in Ireland under the Union: the boundaries of Britishness c.1800-1925
(The University of Edinburgh, 2020-06-26)The aim of this study is to contribute towards historical understanding of how Scottishness, Irishness, and Britishness were constructed and operated within the United Kingdom of Great Britain and Ireland, c.1800-1925. ... -
Development of sustainable catalytic methods for organic synthesis
(The University of Edinburgh, 2020-06-25)This thesis covers two separate projects, but both of which can be linked by the overall aim to develop sustainable catalytic methodology for use in organic synthesis. A concerted effort has been made to move away from ... -
Decision aid to support the use of curative late blight fungicides
(The University of Edinburgh, 2020-07-04)Late blight, caused by the oomycete pathogen Phytophthora infestans (Mont.) de Bary remains a severe threat to potato production in temperate regions and necessitates a high volume of fungicide inputs. A recent focus of ... -
Novel regulators of cancer stem cell biology in acute myeloid leukaemia
(The University of Edinburgh, 2020-06-27)Lifelong haematopoiesis depends critically on a small population of bone marrow resident haematopoietic stem cells (HSCs), which possess unique self-renewal capacity and multilineage differentiation potential, ultimately ... -
Investigating the relationship between depression and cardiovascular diseases in three cohort studies
(The University of Edinburgh, 2020-06-27)Background: Depression and cardiovascular diseases (CVD) are significant public health concerns. Whilst CVD are recognised as the leading cause of death worldwide, depression is responsible for a substantial non-fatal ... -
Initial OCT4 engagement with the somatic proteome during reprogramming to iPSC
(The University of Edinburgh, 2020-06-27)Cellular reprogramming to pluripotency can be achieved by using a defined cocktail of transcription factors, converting differentiated somatic cells into induced pluripotent stem cells (iPSCs). These cells behave like ... -
Frequency composition of wall shear stress in animal models of atherosclerosis
(The University of Edinburgh, 2020-06-27)Atherosclerosis and plaque rupture are widely known as multifactorial problems. To isolate the significance of wall shear stress in these problems, the work of this thesis explores the hypothesis that the frequency ... -
Modular robots for sorting
(The University of Edinburgh, 2020-06-25)Current industrial sorting systems allow for low error, high throughput sorts with tightly constrained properties. These sorters, however, are often hardware limited to certain items and criteria. There is a need for ... -
Mechanisms of mechanosensation in Drosophila melanogaster proprioceptors
(The University of Edinburgh, 2020-07-07)Proprioception is the ability to detect position in space. It is necessary for normal motor control and could share molecular mechanisms with other senses, such as hearing. These mechanisms are poorly understood and ... -
RNA landscape of ILF3
(The University of Edinburgh, 2020-07-04)During viral infections, the presence of viral-derived dsRNA triggers a translational shut-off response affecting translation of both host and viral-derived mRNAs. This response is mediated by the phosphorylation ... -
Phenotypic analysis of the CRISPR-engineered G51D α-synuclein rat
(The University of Edinburgh, 2020-06-27)Parkinson’s disease (PD) is a common neurodegenerative disease that is most often idiopathic, but a significant proportion (5-10%) of cases are caused by highly penetrant monogenic mutations. Point mutations and ... -
Predicting failure of dynamic offshore cables by insulation breakdown due to water treeing
(The University of Edinburgh, 2020-07-03)The offshore wind industry has progressed from traditional fixed bottom platforms for the wind turbines to be installed on, to having floating platforms. This allows access to wind resources further offshore that were ... -
Role of WDR35 in the formation of functional cilia
(The University of Edinburgh, 2020-06-27)Cilia are microtubule-based organelles present on the surface of almost all mammalian cells that play key sensory and sometimes motile functions. Defects in cilia structure or function lead to a group of human diseases ... -
Fox and the city: understanding the influence of urban environment on the disease ecology of red foxes
(The University of Edinburgh, 2020-07-04)The “city fox phenomenon” is a relatively new one. The presence of established Red fox (Vulpes vulpes) populations in highly urbanised areas was first reported from London at the beginning of the 20th century; since then ... -
Corrosion and biofouling of offshore wind monopile foundations
(The University of Edinburgh, 2020-07-03)The impact of corrosion and biofouling on offshore wind turbines is considered to be a key issue in terms of operation and maintenance (O&M) which must be better addressed. Early design assumptions for monopile ... -
Spatial transcriptome analysis of the human developmental haematopoietic stem cell niche
(The University of Edinburgh, 2020-07-04)During human embryonic development the first definitive haematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) region between Carnegie stages (CS) 13 to 17. More specifically, these HSCs are considered ... -
“Prized by the tourist”: souvenir books in Victorian Scotland
(The University of Edinburgh, 2020-06-29)Scotland has been a popular tourist destination for over two centuries, with an intensely romantic reputation that persists to this day. This thesis argues that in the mid-Victorian era, this reputation was developed and ...
