ERA: Recent submissions
Now showing items 61-80 of 39480
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Macroevolution of virulence shifts in human-infective RNA virus species
(The University of Edinburgh, 2023)Study Objectives: To determine the frequency and distribution of virulence shifts across 40 viral genera that include human-infective RNA virus species using evolutionary discrete trait models. Methods: An inhouse ... -
Delivery of supported self-management in asthma reviews: a mixed methods observational study nested in the IMP²ART programme of work
(The University of Edinburgh, 2023-08-17)BACKGROUND: Supported self-management (SSM) reduces the risk of asthma attacks, improves asthma control and quality of life. During routine primary care asthma consultations, healthcare professional (HCP) communication ... -
Hydrogen as a Storage Medium in Scotland
(Gemserv, 2023-08)This report investigates the options for hydrogen storage and its potential for reducing curtailment and providing energy storage in Scotland. The role of hydrogen peaking power for electricity generation during times of ... -
Farmer networks and the adoption of agricultural innovations in East Africa
(The University of Edinburgh, 2023-08-17)The adoption of agricultural innovations is limited across sub-Saharan Africa (SSA) which has resulted in low levels of productivity and exacerbated food security concerns. As a result, it is a key priority of many African ... -
Efficacy of oral corticosteroids for preschool wheeze
(The University of Edinburgh, 2023-08-17)INTRODUCTION: Acute preschool wheeze is one of the most common respiratory conditions in children aged 1 to 6 years. Due to its high prevalence, it consumes substantial healthcare resources and creates economic burdens. ... -
Evaluating the long-term effect of respiratory syncytial virus (RSV) infection on children: a prospective longitudinal birth cohort study in Bangladesh
(The University of Edinburgh, 2023-08-17)BACKGROUND: Respiratory Syncytial Virus (RSV) is a leading cause of illness among neonates and young infants. In 2019, an estimated 33 million [95% CI: 21·6-50·3) RSV-associated acute lower respiratory infected (RSV-ALRI) ... -
Non-invasive imaging of fibrosis with positron emission tomography in a rat model with systemic hypertension and myocardial fibrosis
(The University of Edinburgh, 2023-08-16)Heart failure is one of the leading causes of death worldwide. Hypertension can initiate myocardial remodelling processes which, often via fibrotic triggers through the renin-angiotensin-aldosterone system, can lead to the ... -
Transcriptional regulation and DNA damage response of extrachromosomal DNA in human glioblastoma stem cells
(The University of Edinburgh, 2023-08-16)Glioblastoma is a cancer characterised by limited treatment options and poor prognosis. Glioblastoma is driven by neural stem cell-like cells and is characterised by intratumoral heterogeneity. Extrachromosomal DNA ... -
Associations between glucocorticoids, risk for dementia and early Alzheimer’s disease
(The University of Edinburgh, 2023-08-16)Originally conceived of as a disease associated with old age, Alzheimer’s disease (AD) is now considered to have its earliest origins in midlife. There is considerable interest in understanding more about modifiable risk ... -
Higher-order interactions in single-cell gene expression: towards a cybergenetic semantics of cell state
(The University of Edinburgh, 2023-08-16)Finding and understanding patterns in gene expression guides our understanding of living organisms, their development, and diseases, but is a challenging and high-dimensional problem as there are many molecules involved. ... -
Where ‘green’ parenting meets climate activism: understanding the affective, political, generative, but challenging ‘space in-between’ of radical eco-parenting
(The University of Edinburgh, 2023-08-16)The failure of governments to tackle the climate and ecological crisis challenges normative responsibilities of parents to protect and provide for their children’s future. Recently emerged parent-led climate action groups ... -
Impact of institutional complexity on the role of middle managers as agents of change in the public sector
(The University of Edinburgh, 2023-08-15)The last 30 years has seen a rise in international public sector reform, as governments attempt to reduce public expenditure, and this trend shows little sign of abating. In the UK public sector reform has led to the ... -
Investigating the evolutionary conservation of inflammatory cell migration in vivo
(The University of Edinburgh, 2023-08-15)Inflammation is a complex, dynamic process, which despite extensive research, is still far from fully understood. The use of model organisms provides unique insights into the mechanisms underlying inflammatory cell ... -
Omics basis of human health: investigating plasma proteins and their genetic effects on complex traits
(The University of Edinburgh, 2023-08-15)Over the past decade, the advancements in technology and the growing amount of identified genetic variants have led to a high number of important discoveries in the field of precision medicine concerning human biology and ... -
Testamentary law in England, c. 1450-1540
(The University of Edinburgh, 2023-08-15)In the period between approximately 1450 and 1540, testamentary law and practices within England underwent significant change. This change manifested in several aspects, the most prominent of which was the shift from ... -
Contemporary poetic cinema through the lens of traditional Chinese poetics
(The University of Edinburgh, 2023-08-15)This thesis investigates the aesthetics of contemporary poetic cinema by Alexander Sokurov, Wong Kar-wai and Terrence Malick within a framework of ancient Chinese theories of poetry. I compare these theories to some other ... -
Data-driven modelling and control of concentric tube robots with application in distal lung sampling
(The University of Edinburgh, 2023-08-14)This research aims to explore the use of Concentric Tube Robots (CTRs) as a novel alternative to needle-based interventions in order to make these procedures more accurate and repeatable. CTRs due to their small footprint, ... -
Intervention, participation, perception: case studies of language activism in Catalonia, Norway & Scotland
(The University of Edinburgh, 2023-08-14)This thesis brings together and contextualises three papers, each examining a case-study of language activism. The corresponding research project presents linguistic ethnographic and discourse analytical research in the ... -
Rigorous treatment of Meek's method for single transferable vote with formal proofs of key properties
(The University of Edinburgh, 2023-08-14)This thesis presents a mechanised formalisation of key concepts and properties of Meek's method of Single Transferable Vote (STV). This method is currently in use in a number of local elections in New Zealand, the Royal ... -
Evaluation of low-cost Earth observations to scale-up national forest monitoring in Miombo Woodlands of Malawi
(The University of Edinburgh, 2023-08-14)This study explored the extent that low-cost Earth Observations (EO) data could effectively be combined with in-situ tree-level measurements to support national estimates of Above Ground Biomass (AGB) and Carbon (C) in ...
