Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Functional brain imaging of facial emotion processing in individuals with intellectual impairments
(The University of Edinburgh, 2020-06-27)From the relatively early descriptions of fragile X syndrome, it was recognised that there were differences in social communication, which overlapped or mirrored those seen in idiopathic autism. And in parallel, genetic ... -
Influence of technology on social interaction and play in autistic children
(The University of Edinburgh, 2020-06-27)The social and communication differences associated with autism can make engaging in social play difficult for autistic children. However, it has been suggested that digital technologies could motivate or inspire ... -
Patient-led functional genomics identifies novel drivers of intrahepatic cholangiocarcinoma
(The University of Edinburgh, 2020-06-27)Intrahepatic cholangiocarcinoma (iCCA) is a rare and universally lethal malignancy arising in the liver. Incidence has steadily been increasing globally yet effective therapeutics are lacking. Currently, gold standard ... -
Effect of cortical bone decollagenisation on fracture biomechanics at low strain rate
(The University of Edinburgh, 2020-06-27)Introduction The ability of bone to resist failure is directly dependant on the intrinsic properties, namely the inorganic (hydroxyapetite) and organic (collagen) contents. Traditionally, inorganic content has been ... -
Assessing the functional heterogeneity of human perivascular cells
(The University of Edinburgh, 2020-06-27)Perivascular cells found in multiple organs give rise to mesenchymal stromal/stem cells or MSCs in vitro. These include adventitial cells (CD34+ CD146- CD31- CD45-) isolated from large vessels and pericytes (CD34- ... -
Clinical features and prognosis of ‘scan negative’ uro-neurological disorders
(The University of Edinburgh, 2020-06-27)Uro-neurological disorders are those in which there is a disturbance of bladder function related to a neurological cause. However, many patients with a combination of urological and neurological symptoms, such as bladder ... -
Mms6 expression in adipose-derived mesenchymal stem cells: development of biogenic magnetic nanoparticles and Its therapeutic potential
(The University of Edinburgh, 2020-06-27)Magnetic nanoparticles (MNP) are attracting interest for a range of biomedical applications being used either alone or as part of cell-based therapies. An area of particular interest is magnetic nanoparticle-mediated ... -
Origins and phenotypic heterogeneity of macrophages in endometriosis
(The University of Edinburgh, 2020-06-27)Endometriosis is a chronic inflammatory disorder associated with pelvic pain and infertility that affects ~176 million reproductive age women worldwide. It is defined by the presence of endometrial-like tissue outside the ... -
Investigating glucocorticoids as mediators of increased bone marrow adiposity and bone loss
(The University of Edinburgh, 2020-06-27)In addition to white and brown adipose tissue (WAT and BAT, respectively), there is a third major adipose depot, called bone marrow adipose tissue (BMAT), the formation and function of which is poorly understood. In healthy ... -
Relevance of aldehydes in understanding gene-drug interactions and cancer subpopulations
(The University of Edinburgh, 2020-06-27)Aldehyde dehydrogenase (ALDH) enzymes are key for the metabolism and detoxification of aldehydes and biosynthesis of molecules critical for cellular function. ALDHs are highly expressed in stem cells and are considered ... -
Transcriptional analysis of astrocytes reveals protective functions during remyelination
(The University of Edinburgh, 2020-06-27)In Multiple Sclerosis (MS), the insulating membrane that ensheaths axons termed myelin, is lost by a process known as demyelination. Initial regeneration of myelin, termed remyelination, restores neuronal function. ... -
Infertility-associated DAZL mutations and their effects on DAZL functions
(The University of Edinburgh, 2020-06-27)DAZL (DAZ-Like) is a member of the Deleted in Azoopermia (DAZ) family of RNA-binding proteins, consisting of DAZ, DAZL and BOULE. DAZ is the founding member of the family, and deletions of the Y-chromosome encoded DAZ genes ... -
Epidemiology and outcome of fractures in elderly and super-elderly patients
(The University of Edinburgh, 2020-06-27)Introduction Over the next decade it is predicted that there will be an increase in the elderly (≥65 years old) population within Western society especially those aged 80 years or more (super-elderly). Associated with this ... -
Characterising the in vitro conversion of mouse fibroblasts into induced neurons using a CRISPR/Cas9 knock-out screen
(The University of Edinburgh, 2020-06-27)As the global phenomenon of population aging has become very prominent in the last few decades, diseases of the aging such as Alzheimer’s and Parkinson’s disease have taken the spotlight as the new challenges of modern ... -
There and back again: functional outcomes of reciprocal neuron-astrocyte signalling
(The University of Edinburgh, 2020-07-07)Neurons do not exist in isolation in the central nervous system, and there is a growing appreciation that the interactions between neuronal and non-neuronal cells are fundamentally important for nervous system function. A ... -
Preclinical investigation of the novel SRC inhibitor eCF506 in cancer
(The University of Edinburgh, 2020-06-27)The non-receptor tyrosine kinase SRC plays an important and context-dependent role in a variety of cell signalling pathways that regulate cell motility, survival, division and growth factor signalling. SRC activity has ... -
Investigating the mechanism of FOXG1 in glioblastoma stem cells
(The University of Edinburgh, 2020-06-27)Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer in adults. Relapse after conventional surgery and chemo/radiotherapy is thought to be driven by glioblastoma stem cells (GSCs). GSCs have ... -
Multi-modality imaging assessment of cerebral small vessel disease biomarkers after stroke due to spontaneous intracerebral haemorrhage
(The University of Edinburgh, 2020-06-27)In most cases, spontaneous intracerebral haemorrhage (ICH) is thought to result from cerebral small vessel diseases (SVDs). Cerebral amyloid angiopathy (CAA) and arteriolosclerosis (non-CAA SVD) are the two main types of ... -
Germline variants associated with alternative splicing in colonic mucosa
(The University of Edinburgh, 2020-06-27)The heritability of colorectal cancer (CRC) has been estimated between 7.4% and 26% from a range of analyses based on family lineages and genetic similarity. Certain rare, high penetrance variants are well characterized, ... -
Neck of humerus fractures: epidemiology, predictors of nonunion and classification
(The University of Edinburgh, 2020-06-27)Proximal humerus fractures are common, accounting for 5% of fractures to the appendicular skeleton. Neck of humerus fractures (NHF) account for approximately 80% of all fractures of the proximal humerus – the remainder ...
