Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Development of single-molecules techniques to study native α-Synuclein aggregates
(The University of Edinburgh, 2022-10-04)It is now widely recognised that α-Synuclein (αSyn) oligomers are the main pathogenic species in Parkinson’s Disease (PD). In addition to being cytotoxic they are also thought to play a central role in the interneuronal ... -
Mechanistic insights into Cholangiocyte pathobiology following Primary Cilia loss
(The University of Edinburgh, 2022-10-04)Primary cilia (PC) are sensory organelles that project from the apical membranes of most mammalian cell types and are essential for proper development of the embryo and homeostasis in adult tissues. Disruption to cilia ... -
Breathomics in liver disease
(The University of Edinburgh, 2022-11-26)BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis and end-stage liver disease. The prevalence is increasing in line with the global obesity epidemic. There is a need to develop a non-invasive ... -
Generation of transgenic zebrafish to study podocyte biology
(The University of Edinburgh, 2022-11-26)The Global Burden of Disease Study has shown that kidney disease is one of the fastest rising causes of mortality worldwide and claims 1.1 million lives per year. A range of factors can cause kidney damage. The kidneys ... -
Utilising renal ultrasound insonation to augment serum detection of miRNA biomarkers of renal injury, fibrosis and repair
(The University of Edinburgh, 2022-09-28)[No Deposit Agreement] -
Optimising the use of cardiac biomarkers in the diagnosis and risk stratification of patients in the Emergency Department
(The University of Edinburgh, 2022-09-28)Patients with suspected acute coronary syndrome and acute heart failure account for a very large number of emergency presentations to hospital, however the diagnosis can be challenging because many other life-threatening ... -
Investigating the role of chronic inflammation and stress on the neurobiological features of major depressive disorder
(The University of Edinburgh, 2022-09-28)Chronic inflammation and stress are both implicated in the aetiology of Major Depressive Disorder (MDD); however, the relationships between inflammation, stress hormones, brain structure and depression remain unclear, ... -
Reiterative de novo methylation maintainsmethylation levels in somatic cells
(The University of Edinburgh, 2022-09-28)DNA methylation is a pervasive epigenetic mark in normal cells. DNA methylation abnormalities are a fundamental hallmark of cancer that can promote carcinogenesis. DNA methylation is lost specifically in heterochromatic ... -
Dentine matrix proteins solubilised by 17% ethylenediaminetetraacetic acid and 7% maleic acid and their influence on human dental pulp stem cells: an in vitro study
(The University of Edinburgh, 2022-09-23)INTRODUCTION: Regenerative endodontic procedures have been practiced approximately over the past twenty years. These regenerate pulp-like tissue within the root canals of immature permanent teeth with pulpal necrosis which ... -
Recombinant complement factor H in complement-mediated diseases
(The University of Edinburgh, 2022-09-21)Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 ... -
Investigating the role of R2TP-like co-chaperone complexes during axonemal dynein assembly
(The University of Edinburgh, 2022-09-02)Motile cilia are specialised cell-types which in humans have important roles in the linings of the airways, the reproductive system and the brain. The movement, required for this type of cilia to function, is facilitated ... -
Investigating the effects of 16p11.2 Microdeletion on progenitors and interneuron development using region-specific brain organoids
(The University of Edinburgh, 2022-09-02)Copy number variations (CNVs) of chromosomal region 16p11.2 are genetically linked to 1% of Autism Spectrum Disorder (ASD) cases. This 600kbp region contains 29 genes, but the functions of many genes in this CNV remain ... -
Investigating PAX6 and SOX2 dynamic interactions at the single molecule level in live cells
(The University of Edinburgh, 2022-09-01)The abundance of transcription factor (TF) molecules in the nuclei of eukaryotic cells are in the range of thousands. However, the functional binding sites of most TFs lie in the range of hundreds. This suggests that ... -
Overcoming barriers to cross-disciplinary research
(X-Net project, 2022-08)Interdisciplinary research can create many scientific opportunities but may also face challenges and barriers. X-Net’s main objective is helping interdisciplinary scientists to overcome those barriers providing guidance ... -
Investigating regulatory mechanisms for COL5A1 expression in the human cornea in health and disease
(The University of Edinburgh, 2022-08-01)Keratoconus is a complex corneal condition that is characterised by progressive corneal thinning and significant irregular astigmatism and eventual visual loss. The aetiology of keratoconus is not known although genetics ... -
Defining lineage plasticity of hepatic progenitor cells using transcriptomics and epigenomics
(The University of Edinburgh, 2022-08-01)Hepatocyte turnover becomes abrogated during chronic liver injury, resulting in an impaired liver function and the eventual onset of cirrhosis, only treatable with organ transplant. In this scenario of repeated damage, ... -
Macrophage WNT signalling in liver disease and regeneration
(The University of Edinburgh, 2022-08-30)Liver disease is still a clinical challenge. Even though the liver has a regenerative capacity, it can be impaired during acute or chronic injuries. Paracetamol overdose is the leading cause of acute liver injury ... -
Regulation of neutrophilic inflammation by the nutritional microenvironment
(The University of Edinburgh, 2022-08-30)Neutrophils are the most abundant leucocyte in blood and are rapidly recruited to sites of infection or injury to restore homeostasis. Such inflammatory sites are characterised by hypoxia and nutrient depletion and ... -
Adapting, evaluating and implementing pulmonary rehabilitation in Bangladesh
(The University of Edinburgh, 2022-08-22)[No Deposit Agreement] -
Multimethod examination of the status of emergency care in Ugandan health facilities
(The University of Edinburgh, 2022-08-17)Emergency care is a vital component of any functioning healthcare system, required to rapidly address a vast array of time-critical conditions and thereby reduce their associated morbidity and mortality. At present a wide ...
