Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
Collections in this Community
Recent Submissions
-
Standardisation of preclinical PET/CT protocols across multiple research centres
(The University of Edinburgh, 2020-06-27)Preclinical Positron Emission Tomography/Computed Tomography (PET/CT) is a well-established non-invasive imaging tool for studying disease development/progression, the development of novel radiotracers and pharmaceuticals ... -
Molecular characterisation of human prion amplification in cell-free systems and diagnostic applications
(The University of Edinburgh, 2020-06-27)Prion diseases are a group of fatal neurodegenerative diseases associated with proteopathy occurring in humans and other mammals. The mechanism of prion replication is thought to be based on the induced misfolding of the ... -
Novel regulators of cancer stem cell biology in acute myeloid leukaemia
(The University of Edinburgh, 2020-06-27)Lifelong haematopoiesis depends critically on a small population of bone marrow resident haematopoietic stem cells (HSCs), which possess unique self-renewal capacity and multilineage differentiation potential, ultimately ... -
Investigating the relationship between depression and cardiovascular diseases in three cohort studies
(The University of Edinburgh, 2020-06-27)Background: Depression and cardiovascular diseases (CVD) are significant public health concerns. Whilst CVD are recognised as the leading cause of death worldwide, depression is responsible for a substantial non-fatal ... -
Initial OCT4 engagement with the somatic proteome during reprogramming to iPSC
(The University of Edinburgh, 2020-06-27)Cellular reprogramming to pluripotency can be achieved by using a defined cocktail of transcription factors, converting differentiated somatic cells into induced pluripotent stem cells (iPSCs). These cells behave like ... -
Frequency composition of wall shear stress in animal models of atherosclerosis
(The University of Edinburgh, 2020-06-27)Atherosclerosis and plaque rupture are widely known as multifactorial problems. To isolate the significance of wall shear stress in these problems, the work of this thesis explores the hypothesis that the frequency ... -
Mechanisms of mechanosensation in Drosophila melanogaster proprioceptors
(The University of Edinburgh, 2020-07-07)Proprioception is the ability to detect position in space. It is necessary for normal motor control and could share molecular mechanisms with other senses, such as hearing. These mechanisms are poorly understood and ... -
Phenotypic analysis of the CRISPR-engineered G51D α-synuclein rat
(The University of Edinburgh, 2020-06-27)Parkinson’s disease (PD) is a common neurodegenerative disease that is most often idiopathic, but a significant proportion (5-10%) of cases are caused by highly penetrant monogenic mutations. Point mutations and ... -
Role of WDR35 in the formation of functional cilia
(The University of Edinburgh, 2020-06-27)Cilia are microtubule-based organelles present on the surface of almost all mammalian cells that play key sensory and sometimes motile functions. Defects in cilia structure or function lead to a group of human diseases ... -
Somato-dendritic coupling in layer 5 pyramidal neurons of the mouse primary visual cortex
(The University of Edinburgh, 2020-07-07)Cortical layer 5 excitatory neurons are characterized by long apical dendrites receiving inputs from multiple long-range cortical and subcortical connections. In vitro and in vivo recordings have shown that the dendrites ... -
Development of tools to explore the fundamentals of axonemal dynein heavy chain biology and improve the efficiency of genome editing
(The University of Edinburgh, 2020-06-27)Motile cilia are microtubule based projections that assist in the movement of fluid over the surface of cells, such as in the respiratory epithelium, or of cells through a fluid, such as in sperm. Ciliary movement is ... -
Disputatio medica inauguralis de erysipelate contagioso
(The University of Edinburgh, 1813)Primum hunc gradum et quasi studiorum principium initurus, quam Academiae usus praebet, occasionem tuae in me meosque benignitatis agnoscendte lubentissimtè arripio. -
PRC1 organizes 3D chromatin architecture in mouse ES cells
(The University of Edinburgh, 2020-06-27)Polycomb is a major epigenetic pathway involved in developmental gene regulation. While currently it is not understood how Polycomb Repressive Complexes (PRCs) silence genes, regions of the genome bound by polycomb are ... -
Origin and maintenance of Kupffer Cells in homeostasis and liver injury
(The University of Edinburgh, 2020-06-27)Evaluation of liver resident Kupffer Cells (KC) has shown that in mouse these cells derive from a population of foetal liver monocytes that seed the tissues during embryogenesis and maintain themselves in steady state ... -
OMICs based identification of the mechanisms that underpin FAK’s regulation of gene expression
(The University of Edinburgh, 2020-06-27)Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase, commonly overexpressed in cancer that is well known to be a key regulator of cancer cell proliferation, survival, migration and invasion. It has recently ... -
Investigation of PML locus on chr15 for susceptibility to Paget’s disease of bone
(The University of Edinburgh, 2020-06-27)Paget’s disease of bone (PDB) is a common bone disorder. The disease is characterised by localised abnormalities in bone turnover (Ralston et al. 2008). Genetic factors are important for PDB. Genome-wide association studies ... -
Role of multilevel policy initiatives in promoting the earlier diagnosis of cancer – what can we learn from the Detect Cancer Early Programme in Scotland?
(The University of Edinburgh, 2020-06-27)Background: Early cancer detection and early diagnosis have a key role in multilevel policy initiatives aiming to improve cancer outcomes. In Scotland, the Detect Cancer Early (DCE) Programme was launched in 2012 with ... -
Coherent fibre bundle-based fluorescence imaging: optimising visualisation of pulmonary alveolar pathology
(The University of Edinburgh, 2020-06-27)The focus of this PhD is to develop fibre-based imaging systems for the lung which can be used in conjunction with fluorescent chemical probes. Together, the imaging systems and the probes could provide a clinician with ... -
Impact of DNA sequence on the structure and dynamics of the higher-order chromatin fibre in vitro
(The University of Edinburgh, 2020-06-27)DNA in the eukaryotic cell is organised into a complex called chromatin, which protects the DNA from damage and allows the careful regulation of the genome. Precisely how the genome is used by the cell is dependent on ... -
Muscle factors and demographic characteristics affecting early functional outcome following total knee arthroplasty
(The University of Edinburgh, 2020-06-27)Primary total knee arthroplasty (TKA) for end-stage osteoarthritis (OA) is a surgical procedure with a long history of successful outcomes. However, one fifth of patients report dissatisfaction with the outcome of surgery ...
