Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Tentamen physiologicum inaugurale, de concoctione ciborum
(The University of Edinburgh, 1821)The boundaries between nature animals and plants placing the alimentary canal us The highest support. Zoophytes that bond to set up a connection between the two, it seems, endowed with a simple cavity, in which Absorption ... -
Germline genetic variations and survival outcomes of colorectal cancer
(The University of Edinburgh, 2020-06-27)BACKGROUND: Colorectal cancer (CRC) was the second commonest cancer and the third leading cause of cancer-related deaths worldwide in 2018. In the UK, the overall 5-year survival rate of CRC patients is approximately ... -
Critical assessment of computed tomography as a valid means of muscular body composition analysis in cancer cachexia
(The University of Edinburgh, 2020-06-27)Cancer cachexia is a constellation of symptoms affecting many cancer patients as their disease progresses. These include loss of muscle mass as well as function, and the utility of computed tomography (CT) in defining ... -
Investigating the relationship between SORCS2 and SORLA and DNA double-stranded break formation, as a possible mechanism in neuropsychiatric disorders
(The University of Edinburgh, 2020-06-27)SORCS2 and SORLA are members of the Vps10p-domain receptor family, which comprises five multifunctional neuronal receptors. All family members are involved in intracellular sorting and trafficking of various neurotrophic ... -
Functional characterisation of spontaneously active GABAA receptors in rat dentate gyrus granule cells
(The University of Edinburgh, 2020-06-27)GABAA receptors (GABAARs) are the principal inhibitory neurotransmitter receptors in the adult mammalian central nervous system. GABAARs mediate two forms of inhibition: fast, phasic conductance; and slow, tonic conductance. ... -
Defining and exploiting the developmental origin of MLL-AF4-driven infant Acute Lymphoblastic Leukaemia
(The University of Edinburgh, 2020-06-27)Infant MLL-AF4-driven pro-B Acute Lymphoblastic Leukaemia (ALL) is the most common leukaemia in infants. This devastating disease, which arises in utero, renders the infant patients with an aggressive disease and with a ... -
Retinal vessel traits and their association with diabetic retinopathy and cognitive decline in a population with type 2 diabetes
(The University of Edinburgh, 2020-06-27)Background People with diabetes are at an increased risk of developing vascular disease, which is the leading cause of morbidity and mortality in this population. The retina is one of the few places in the body that offers ... -
Modelling adipose tissue expansion in zebrafish
(The University of Edinburgh, 2020-06-27)Obesity has been classified as a global epidemic by the World Health Organisation, with 13% of the world’s adult population estimated to be obese in 2016. An increased risk of multiple diseases is associated with obesity, ... -
Determinants of successful online public engagement campaigns in global health
(The University of Edinburgh, 2020-06-27)Efforts in global health and development have broad political support and substantial financial commitment from most governments. However, global health organisations often have difficulty gaining the support of the public ... -
Evolutionary origin, cyclic peptide targeting and physiological activation of Peptidyl Arginine Deiminase 4
(The University of Edinburgh, 2020-06-27)Five peptidylarginine deiminases (PADIs), regulating diverse aspects of human physiology, catalyse the post-translational modification citrullination in mammals. Deregulation of citrullination underlies the development of ... -
Development of SmartProbes for the optical imaging of pulmonary inflammation
(The University of Edinburgh, 2020-06-27)The prospect of an optical biopsy to interrogate disease within the human lung offers the ability to improve the outcomes of clinical trials, provide early validation within drug discovery programmes, while also offering ... -
Chronic impact of reduced cerebral blood flow on synaptic structure and glial responses
(The University of Edinburgh, 2020-07-07)Vascular cognitive impairment (VCI) results from a heterogeneous range of cerebrovascular injuries, such as stroke, cerebral large and small vessel disease, or cerebral amyloid angiopathy, which reduce cerebral blood ... -
Clinical utility of capsule endoscopy in gastrointestinal bleeding
(The University of Edinburgh, 2020-06-27)Introduction Capsule endoscopy (CE) is a first-line diagnostic tool for known or suspected small bowel bleeding (SBB), and its use has over time been expanded to include panenteric imaging. It offers advantages over ... -
Fracture healing in Human Immunodeficiency Virus positive patients: the HIV in Orthopaedic Skeletal Trauma (HOST) study
(The University of Edinburgh, 2020-06-27)Background: Human immunodeficiency virus (HIV) has been shown to reduce bone mineral density (BMD), mineralisation and bone turnover. In the HIV-negative population, reduced BMD is associated with delayed bone union and ... -
Epidemiology of carbapenemase-producing organisms (CPO) in Scotland
(The University of Edinburgh, 2020-06-27)The emergence and spread of carbapenem-resistant organisms (CRO) is a global public health threat in healthcare settings, resulting in high mortality, prolonged healthcare and increased costs. In the last two decades, many ... -
Risk factors for pre-eclampsia in low and middle-income countries, a case study of Tanzania
(The University of Edinburgh, 2020-06-27)This PhD research focuses on understanding a maternal pregnancy condition known as pre-eclampsia. This condition contributes to around 14 % of the global burden of maternal mortality and fivefold of perinatal mortality in ... -
Global burden of acute lower respiratory infection (ALRI) associated with influenza virus, human metapneumovirus, and human parainfluenza virus among children under five years
(The University of Edinburgh, 2020-06-27)Introduction Acute lower respiratory infection (ALRI) is one of the leading causes of mortality in children under five years. Although childhood ALRI mortality has substantially reduced over the past 15 years, continued ... -
Investigating the causes of chondrocyte death in septic arthritis
(The University of Edinburgh, 2020-06-27)Septic arthritis is a feared disease that can lead to the destruction of joints and result in significant morbidity. It is caused by an infection within a joint and up to 65% of cases are secondary to Staphylococcus aureus. ... -
Functional brain imaging of facial emotion processing in individuals with intellectual impairments
(The University of Edinburgh, 2020-06-27)From the relatively early descriptions of fragile X syndrome, it was recognised that there were differences in social communication, which overlapped or mirrored those seen in idiopathic autism. And in parallel, genetic ... -
Influence of technology on social interaction and play in autistic children
(The University of Edinburgh, 2020-06-27)The social and communication differences associated with autism can make engaging in social play difficult for autistic children. However, it has been suggested that digital technologies could motivate or inspire ...
