Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Design, development, and assessment of novel 3-dimensional co-culture systems to model musculoskeletal interfaces
(The University of Edinburgh, 2019-11-25)The interface between fibrous tissues (ligaments, tendons, cartilages and joint capsules) and bones is known as the enthesis. It has a unique anatomical structure transitioning from pure fibrous tissue to pure bone tissue. ... -
Impact of two autism related genes on amygdala physiology
(The University of Edinburgh, 2019-11-25)Intellectual disability (ID) and autism spectrum disorder (ASD) are two of the most common developmental disorders affecting 3–5% of the population. These disorders have a high burden on society with no efficient treatment ... -
Investigating the protein targets of the neuroprotective E3 ligase, CHIP
(The University of Edinburgh, 2019-11-25)Identifying early defects in protein homeostasis (“proteostasis”) in neurodegeneration could shed light into disease-promoting events and provide promising therapeutic targets for disease modification. A key player in ... -
Identifying and overcoming mechanisms of resistance to Wee1 kinase inhibitor (AZD1775) in high grade serous ovarian cancer
(The University of Edinburgh, 2019-11-25)High grade serous ovarian cancer (HGSOC) comprises 75-80% of all ovarian cancer cases and is characterised by p53 mutation and genetic heterogeneity. There are two major molecular categories: homologous recombination ... -
Genetic programming of human iPSC-derived macrophages provides a tool to study the Erythroblastic Island niche in vitro
(The University of Edinburgh, 2019-11-25)Macrophages have been attracting much attention as they are present in many tissues and organs, and are involved in homeostatic tissue function and disease. Studies involving human macrophages have been hampered due to ... -
Epidemiology of antimicrobial resistance at the livestock-human interface in an urban environment: a One Health approach
(The University of Edinburgh, 2019-11-25)Livestock have been implicated as a reservoir for antimicrobial resistant (AMR) bacteria that may spread to humans, with the keeping of livestock widely postulated as a risk factor for AMR in humans. However, quantitative ... -
Translational control of mRNAs in the brain in health and disease: investigations into protein synthesis in the brain and related neuropsychiatric disorders
(The University of Edinburgh, 2019-11-25)Neuropsychiatric disorders, e.g. autism spectrum disorders and depression, present an increasing burden on society. Diagnoses are on the rise and despite a constantly increasing body of research, causes and mechanisms ... -
Role of ANLN in post ischaemic angiogenesis
(The University of Edinburgh, 2019-11-25)Angiogenesis is a key physiological process by which new blood vessels are dynamically formed in Endothelial cell (EC) driven processes. The identification of new potential genes of interest in ECs can help to further ... -
Identification of novel IFITM1/IFITM3 signalling pathways implicated in the interferon response
(The University of Edinburgh, 2019-11-25)Interferon induced transmembrane protein 1 (IFITM1) is an interferon (IFN) stimulated protein upregulated during development of radiation resistance in cancer. It is present in resistant tumours, generating a multi-drug ... -
Women’s experiences of sterilisation in Brazil: negotiating reproductive discourses, institutional and intimate relationships, and contraceptive practices
(The University of Edinburgh, 2019-11-25)The dramatic drop of the fertility rate in Brazil, from 6.2 births per woman in 1960 to 2.5 in 1996, has been attributed to women’s increasing use of sterilisation. Despite the fact that sterilisation was illegal, Brazil ... -
Role of 4E-BP2 in neuronal translation
(The University of Edinburgh, 2019-11-25)Translational control is a powerful means to alter gene expression and regulates synaptic plasticity, learning and memory. 4E-BP2 (Eif4ebp2, Eukaryotic Initiation Factor 4E-Binding Protein 2) is the predominantly expressed ... -
Cardiovascular magnetic resonance and positron emission tomography in the assessment of aortic stenosis
(The University of Edinburgh, 2019-11-25)Background Aortic stenosis is not only characterized by progressive valve narrowing but also by the hypertrophic response of the left ventricle that ensues. In this most common valvular condition novel imaging approaches ... -
Global seasonality of respiratory viruses and the association between viral acute respiratory infection and subsequent pneumococcal disease
(The University of Edinburgh, 2019-11-25)Introduction Influenza virus (IFV), respiratory syncytial virus (RSV), parainfluenza virus (PIV), and metapneumovirus (MPV) are the most common viruses associated with acute lower respiratory infections in young children ... -
Genetic responses to environmental stress underlying major depressive disorder
(The University of Edinburgh, 2019-11-25)Major depressive disorder (MDD) is a common psychiatric disorder and a leading cause of disability worldwide. Such illness is the result of a complex interplay between genetic susceptibility and environmental risk ... -
Regulation of calcium signalling in murine corticotrophs
(The University of Edinburgh, 2019-11-25)Anterior pituitary corticotrophs, the central components of the hypothalamic-pituitaryadrenal (HPA) axis, are important for controlling the neuroendocrine response to stress. In response to a stressor, corticotrophin-releasing ... -
Principiis obsta, sero medicina paratur: cum mala per longas convaluere moras
(The University of Edinburgh, 1827)[Latin text] -
Understanding in vivo modelling of depression
(The University of Edinburgh, 2019-11-25)Major Depressive Disorder (MDD) is the leading source of disability globally. Treatment-resistance among patients is common and even effective pharmacological therapies have a delayed effect on symptom relief. Better ... -
Investigating the role of the non-canonical inflammasome in senescence
(The University of Edinburgh, 2019-11-25)Cellular senescence is a permanent proliferative arrest of cells triggered by several different stress mechanisms. Senescent cells display an inflammatory phenotype termed the senescence-associated secretory phenotype ... -
Investigation of the tissue origins of cellfree DNA and candidate biomarkers for liquid biopsy
(The University of Edinburgh, 2019-11-25)Liquid biopsy is the sampling and analysis of analytes from various biological fluids to detect and diagnose cancer, for which it is an alternative to solid tissue biopsy for the detection of cancer. Compared to solid ... -
Role of exogenous Interleukin 4 in modulating the mononuclear phagocyte response to acute liver injury.
(The University of Edinburgh, 2019-11-25)Background Acute liver failure has significant mortality for which the only reliable treatment is transplantation. Murine models of acute liver injury are characterised by dramatic changes in the hepatic macrophage ...
