Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Functional genomics interrogation of gene-environment interactions between vitamin D and genetic variants associated with colorectal cancer susceptibility
(The University of Edinburgh, 2021-12-08)Colorectal cancer (CRC) is the fourth most common cancer in the UK. It develops in a step-wise manner from normal tissue to cancerous tumour over many years. The heritability of CRC risk is estimated variously up to 35%. ... -
Children ́s experiences of living with Cleft Lip and Palate (CLP): a qualitative study in Colombia
(The University of Edinburgh, 2021-12-08)This thesis explores children ́s views and experiences of living with CLP in three regions of Colombia. CLP is a birth condition resulting from a failure in the development of facial structures during the development of ... -
Exploration of online postgraduate education: an evolving pedagogy
(The University of Edinburgh, 2021-08-27)This thesis outlines an evolving understanding of online postgraduate healthcare education and proposes a pedagogical model to conceptualise the process. It draws together six peer-reviewed publications on the subject ... -
Could statins be a novel therapeutic for the prevention of preterm delivery? Evidence from an animal model and Phase II feasibility trial
(The University of Edinburgh, 2021-12-08)Preterm delivery affects 15 million pregnancies annually, and is the leading cause of mortality in the under 5s globally. Spontaneous preterm delivery accounts for 70% of these, and novel preventative strategies are ... -
Analysis of the kinomic and immune cancer synapse in GBM
(The University of Edinburgh, 2021-12-08)A deeper understanding of the signalling networks operating in vivo is needed to develop more physiologically relevant ex-vivo models and support the discovery of new therapeutics in human cancer. An example is human ... -
Oncogenic selection of germline and somatic variants
(The University of Edinburgh, 2021-12-08)Most cancers are caused by a combination of inherited germline variants and somatically acquired mutations that drive cellular dysregulation. Cancer genomics aims to distinguish functional cancer-causing genetic variants ... -
Novel therapies for the prevention and management of orthopaedic biomaterial associated Staphylococcus aureus infections
(The University of Edinburgh, 2021-12-08)The use of implanted biomaterials to augment the human body in the treatment of musculoskeletal conditions is one of the great successes of modern medicine. However implanted biomaterials create a unique ecological ... -
Investigating CDK9 inhibitor treatment during the innate inflammatory and regenerative response in a zebrafish model of cardiac injury
(The University of Edinburgh, 2021-12-08)Neutrophils and macrophages are crucial effectors and modulators of cardiac repair following myocardial infarction (MI). Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse ... -
Depression in autistic adults: measurement and social risk factors
(The University of Edinburgh, 2021-12-08)Depression appears to affect a substantial proportion of the autistic population. Yet there is a lack of evidence for reliable tools for measuring depression in autistic people, and of the factors which contribute to ... -
Scottish clinical outcomes following kidney transplantation: the SCOT-network
(The University of Edinburgh, 2021-12-08)BACKGROUND: In the era of ageing populations, the proportion of older patients reaching End Stage Renal Disease is on the rise and an increasing proportion of patients require a second or subsequent transplant during their ... -
Novel mechanisms regulating the membrane recruitment of the ATG8 conjugation machinery
(The University of Edinburgh, 2021-07-31)Autophagy is a highly conserved eukaryotic process that maintains cell viability by targeting excess or damaged cytoplasmic material for lysosomal degradation. This process involves the generation of a double-membraned ... -
Breast cancer incidence and survival trends by molecular subtypes in Scotland
(The University of Edinburgh, 2021-07-31)Background: Breast cancer (BC) is the most common cancer among women and leading contributor to cancer mortality, hence constitutes a major public health issue worldwide. In Scotland, over 4,000 women are diagnosed ... -
Molecular and therapeutic stratification of endometrioid ovarian carcinoma
(The University of Edinburgh, 2021-07-31)Epithelial ovarian carcinomas (EOC) comprise five main histological subtypes, each displaying distinct pathological, molecular and clinical characteristics. Endometrioid ovarian carcinomas (EnOC) account for 10% of EOC ... -
Common genetic variance at the SMAD9 colorectal cancer risk locus influences tumour mutational phenotype
(The University of Edinburgh, 2021-07-31)I set out to investigate whether common germline variance associated with colorectal cancer (CRC) risk can influence the somatic mutational landscapes of CRC. Some Mendelian cancer syndromes, such as Lynch syndrome ... -
Reviewing people with Obstructive Sleep Apnoea Hypopnoea Syndrome: telehealth and templates
(The University of Edinburgh, 2021-07-31)Introduction Obstructive Sleep Apnoea Hypopnoea Syndrome (OSAHS) is estimated to affect one billion people globally, carrying a substantial risk of road traffic accidents due to daytime sleepiness with additional other ... -
Exploring how Japanese family physicians understand palliative care and identify patients for primary palliative care
(The University of Edinburgh, 2021-07-31)Background: Primary care clinicians have great potential to play a key role in providing palliative care in the community. However, difficulties in identifying patients for palliative care hinders progress. This problem ... -
New insights into probabilistic pattern formation of embryonic stem cells using agent-based modelling
(The University of Edinburgh, 2021-07-31)Embryonic stem cells (ESCs) hold great potential for developing future therapies for a wide range of diseases. However, the mechanisms of pattern formation during embryonic development remain poorly understood. ESCs in ... -
Allosteric regulation of the AAA+ superfamily protein reptin
(The University of Edinburgh, 2021-07-31)Reptin is a member of the AAA+ (adenosine triphosphatase associated with diverse cellular activities) protein superfamily with roles in many protein complexes and interactions which have been indicated in cancer including ... -
Role of IL6ST in endocrine sensitivity of breast cancer
(The University of Edinburgh, 2021-07-31)Breast cancer is the most common type and cause of cancer death in women. Oestrogen is a major growth stimulant of oestrogen receptor alpha (ERa) positive breast cancer and consequently, endocrine therapy which targets ... -
Role of perinatal inflammation in preterm brain injury
(The University of Edinburgh, 2021-07-31)Perinatal inflammation is associated with an increased risk of brain injury and neurodevelopmental impairment in preterm infants but the immune mediators driving this association are not well understood. This PhD thesis ...
