Edinburgh Medical School
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
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Bilingualism in autism: A neurocognitive investigation of the influence of bilingualism on perspective-taking in autistic adults
(The University of Edinburgh, 2020-11-30)Autism spectrum disorder (hereafter autism), is a lifelong neurodevelopmental condition with current prevalence estimates ranging around 1/100 worldwide. Autism is manifest in multiple forms, but always entails differences ... -
Studies with the bacteriophages of Escherichia coli
(The University of Edinburgh, 1966)In this Thesis a study is made of a number of episome-host relationships, with emphasis placed on use of the recombination-deficient bacterial cell as a new tool for examining the phenomena of transduction, lysogenization ... -
Establishing outer membrane Integrity in Klebsiella pneumoniae
(The University of Edinburgh, 2020-11-30)The Outer Membrane (OM) of Gram-negative bacteria is the primary barrier for the cell, with its asymmetric composition of lipopolysaccharides (LPS) at the outer leaflet and glycerophospholipids (GPL) at the inner ... -
Gene-environment interactions in relation to colorectal cancer risk
(The University of Edinburgh, 2020-11-30)Introduction: Colorectal cancer (CRC) is the third most common cancer by incidence and second by mortality worldwide in 2018. Variation in individual genetic susceptibility and environmental exposures both contribute to ... -
Neutrophils in advanced non-small cell lung cancer
(The University of Edinburgh, 2020-11-30)Lung cancer is the third most common cancer in the UK; 87% are histologically nonsmall cell lung cancer (NSCLC). At the time of diagnosis, patients frequently have advanced disease, with poor one-year survival due to ... -
Using mass spectrometry to profile sex steroids in metabolic diseases
(The University of Edinburgh, 2020-11-30)Sex hormones are steroids that are key co-ordinators of sexual development and are principally formed in endocrine glands. The main types of sex hormones in females are estrogens: notably estrone (E1) and estradiol ... -
Relationships between periodontal disease and oral health-related quality of life in the urban older population in Indonesia
(The University of Edinburgh, 2020-11-30)Improvement in prevention of disease and effective management of health are leading to increased life expectancy globally. This increased life expectancy is associated with challenges for the global public health in ... -
Gender inequities in health care utilisation for common infections children under-5 in India
(The University of Edinburgh, 2020-11-30)Common infectious diseases like pneumonia, diarrhoea and malaria, are the leading causes of mortality in young children aged below 5 years, especially in low and middle-income countries (LMICs). Globally, India is the ... -
Probing mechanisms by which cerebral vascular disease may influence cognitive impairment and dementia
(The University of Edinburgh, 2020-11-30)Introduction Vascular cognitive impairment (VCI) describes a full spectrum of cognitive deficits caused by underlying cerebral vascular alterations, regardless of the specific mechanisms involved. Several factors such ... -
A study of the Fife and Kinross District Asylum 1866-1899
(The University of Edinburgh, 1992)This thesis aims to illuminate the hitherto neglected area of the Scottish Victorian Pauper Asylum. It provides a detailed study of one specific institution, The Fife and Kinross District Asylum between the years 1866 ... -
Gonorrhœa virulenta
(The University of Edinburgh, 1823)Morbus, de quo in hoc opusculo, nempe Gonorrhoea, disserere statui, per longum tempus attentionem medici merito sibi attraxit; et multum inter se discrepant auctores, quoad viri naturam quod eam excitat. Multi et ... -
Effect of manipulating PI3K pathway components on primordial follicle activation and DNA damage response in bovine ovarian follicles in vitro
(The University of Edinburgh, 2020-06-27)Developing immature follicles either from fresh or cryopreserved ovarian tissue to attain competent and fertilisable oocytes could provide an option for some patients undergoing fertility preservation to avoid the risk ... -
Constructing success in global health: the World Bank and the Onchocerciasis Control Programme in West Africa
(The University of Edinburgh, 2020-07-27)The Onchocerciasis Control Programme in West Africa (OCP), a United Nations-sponsored initiative that targeted a neglected tropical disease (NTD) from 1974-2002, has been depicted as a major global health success story ... -
DNA-mediated inflammation in pregnancy
(The University of Edinburgh, 2020-07-27)During pregnancy, the maternal immune system must adapt to allow for the growth of a semiallogenic fetus whilst maintaining the ability to respond to pathogens. Maternal immune system adaptions are imperfect. Pregnant ... -
Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
(The University of Edinburgh, 2020-08-07)Autism spectrum disorder (ASD) is a range of developmental brain disorders characterized by poor nonverbal communication skills, impaired behaviour and social interaction, and a limited diversity of social activities and ... -
Investigating the role of chromatin modifications in CRISPR/Cas9 gene editing
(The University of Edinburgh, 2020-07-27)Precisely positioned nucleosomes and heterochromatin have been shown to impede CRISPR/Cas9 editing efficiency. Conversely, Cas9 can open previously inaccessible regions of DNA, and transcriptionally silent targets ... -
Quantitative retinal traits and their association with cardiovascular disease and cardio-metabolic genetic variants in people with type 2 diabetes
(The University of Edinburgh, 2020-07-27)Introduction: Type 2 diabetes (T2D) is one of the most prevalent noncommunicable diseases in the world and its cardiovascular complications present a huge socio-economic burden. In 2015, in the UK alone, 3.8 million people ... -
Explaining how medical doctors learn about and understand the approach to the end-of-life in the workplace
(The University of Edinburgh, 2020-07-27)Background For patients approaching the end-of-life, treatments with life-prolonging intent can be futile, wasteful, and harmful. Equally, harm may be caused by prematurely treating patients as if they are dying. In ... -
Metabolic regulators of inflammation in acute pancreatitis
(The University of Edinburgh, 2020-07-27)Acute pancreatitis (AP) is a common inflammatory disease with multiple aetiological triggers, most commonly gallstones and alcohol consumption, but with no specific treatment. One in four patients with AP develop organ ... -
Optical profiling of macrophages
(The University of Edinburgh, 2020-07-27)Macrophages are required to show plasticity in how they react to their microenvironment and orchestrate an inflammatory response. With such an integral role in human immunity, aberrant macrophage function can directly ...
