Edinburgh Medical School thesis and dissertation collection
Edinburgh Medical School is one of two schools at the College of Medicine and Veterinary Medicine at the University of Edinburgh. The Edinburgh Medical School integrates research and teaching across our three Deaneries: Biomedical Sciences, Clinical Sciences and Molecular,Genetic and Population Health Sciences.
Recent Submissions
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Anti-nuclear factor as an auto-antibody
(The University of Edinburgh, 1962-10)The study of a factor which can be demonstrated using Coons indirect fluorescent antibody technique, in the serum of patients with Systemic Lupus Erythematosus (and some other diseases) has been described. An outline ... -
Gingival inflammation: a study of the distribution of plasma proteins in healthy and inflamed gingival tissues using fluorescent protein tracing
(The University of Edinburgh, 1966)Gingivitis is a widespread disease, which follows a characteristically chronic course with occasional acute exacerbations, and which frequently is slowly progressive. The aetiology and pathogenesis remains unresolved, and ... -
Role of DNA sequence and nucleosome positioning in higher-order chromatin folding
(The University of Edinburgh, 2023-03-21)Chromatin is the substrate for all DNA-associated processes and revealing its structure is key to understanding the regulation of nuclear functions. DNA sequence influences the primary positioning and binding affinity of ... -
Approaches for identifying macrophage microbicidal mechanisms
(The University of Edinburgh, 2023-03-20)Host defence is usually successful in preventing pathogen exposure and colonisation from progressing to invasive disease. However, efforts to identify specific host microbicidal responses that can be therapeutically ... -
Impact of selective progesterone receptor modulators (SPRMs) on the human endometrium
(The University of Edinburgh, 2023-03-20)INTRODUCTION: Heavy menstrual bleeding (HMB) is a common, chronic, debilitating and often underreported condition affecting at least 1 in 4 women of reproductive age. There is an unmet for managing the symptom of HMB. ... -
Investigating the role of DNA methylation in pluripotency and differentiation using an embryoid body model
(The University of Edinburgh, 2023-03-17)Epigenetics is the study of heritable alterations in phenotype caused by changes in cellular properties, but where the genotype is unchanged. At the molecular level these changes include chemical modifications of DNA and ... -
Humeral shaft fractures: epidemiology, outcomes and predictors of nonunion
(The University of Edinburgh, 2023-03-17)Humeral shaft fractures comprise 1% of adult fractures, with isolated, closed injuries usually managed non-operatively in the first instance. However, there is limited data regarding the modern epidemiology of these ... -
Impact of test, risk and diagnostic disclosures in suspected early neurodegenerative disease
(The University of Edinburgh, 2023-03-16)INTRODUCTION: Early detection of mild cognitive impairment (MCI) is important for offering pragmatic risk reduction advice but also for engaging individuals who may be in the prodromal stages of Alzheimer’s disease in ... -
Impact of chemotherapy on the release and function of extracellular vesicles in the pre-pubertal testis
(The University of Edinburgh, 2023-03-16)INTRODUCTION: Childhood cancer affects nearly 2,000 children in the UK each year and encompasses a range of pathologies. The incidence of childhood cancer is rising, and the peak age of onset occurs between 0 - 4 years ... -
Identification of KLF1-E325K as a loss-of-function mutation in iPSC-derived macrophages
(The University of Edinburgh, 2023-03-14)With over two million red blood cells produced every second, erythropoiesis is one of the bodies most demanding processes. It is therefore unsurprising that multiple hereditary and acquired red blood cell disorders arise ... -
Chromatin structure and dynamics at different phases of the cell cycle
(The University of Edinburgh, 2023-03-14)In this thesis I present some results from my research into eukaryotic chromatin structure and dynamics. Chromosome organisation is studied through a simulation approach and at different stages of the cell cycle. Throughout ... -
Adolescent brain and depression: a neuroimaging approach to understanding biological and psychosocial risk factors
(The University of Edinburgh, 2023-03-13)Adolescence is a period of significant neurodevelopment and increased vulnerability to the onset of depression. However, the neural underpinnings of depression during adolescence and the associated risk factors are not ... -
Examining the cumulative effects of stress and immune challenge in early life on the risk of depression and anxiety in adulthood
(The University of Edinburgh, 2023-03-13)During development, there are windows in which the brain is particularly susceptible to the impact of challenges – these include the pre-natal, early post-natal, and peri-pubertal periods. As such, adverse childhood ... -
Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
(The University of Edinburgh, 2023-03-08)The paired-box protein PAX6 is a transcription factor that acts as a master regulator during neurodevelopment. In mice, it is expressed by neural progenitors in the cortical ventricular zone (VZ) where it regulates ... -
Predicting disease in tubulin: investigating isotypes, evaluating computational methods and exploring pathogenic mechanisms
(The University of Edinburgh, 2023-03-07)From assisting division to molecular transport, cells depend on microtubules for several vital functions. Their fundamental nature is reflected in the extensive links between disease and mutations in their building blocks: ... -
Automated retrieval and analysis of published biomedical literature through natural language processing for clinical applications
(The University of Edinburgh, 2023-03-01)The size of the existing academic literature corpus and the incredible rate of new publications offers a great need and opportunity to harness computational approaches to data and knowledge extraction across all research ... -
Identification and targeting of a SOX2 and SOX9 degradation pathway in glioblastoma
(The University of Edinburgh, 2023-02-20)Glioblastoma multiforme (GBM) is the most malignant adult brain tumour. A subpopulation of cells, termed glioblastoma stem cells (GSCs), possesses similar phenotypic characteristics to normal neural stem cells (NSCs) and ... -
In vitro heterogeneity of human oligodendroglia
(The University of Edinburgh, 2023-02-14)Oligodendrocytes in the central nervous system (CNS) wrap their plasma membrane extensions around large calibre neuronal axons formulating the multi-layered myelin sheath. Myelin is essential since it allows fast conduction ... -
In silico investigation of the haematological niche during normal and malignant haematopoiesis
(The University of Edinburgh, 2023-02-13)Eradicating leukaemia stem cells (LSCs) and curing stem cell-derived cancers is hugely challenging. This is exemplified in chronic myeloid leukaemia (CML), where the t(9;22)(q34;q11) chromosomal translocation results in ...
