CHEMISTRY: Salvarsan is thedi-hydrochloride of
dioxy-diamido-arseno-benzol. It is a pentavalent
SOLUTION FOR INJECTION: The di-sodium salt of Salvarsan was used for intravenous injections. It is dissolved in .85% normal saline, and is diluted so that
every 40 c.c's of the solution contains .1 grammes of
DOSAGE: In practically every case .5 grammes Salvarsan was injected each time. As a rule not less than
two injections were given at intervals of fourteen to
twenty-one days. If necessary a further injection
was administered, the indications being controlled by
the Wassermann reaction.
APPARATUS USED: The apparatus used was the one devised by Gibbard.
DIAGNOSIS OF CASES: All cases treated had the diagnosis confirmed by either emonstrating the Treponema
Pallidum in serum from the lesions, or by the performance of a Wassermann reaction. After treatment and
progress of cases were controlled by the Wassermann
PREPARATION OF PATIENT FOR THE INJECTION: Patients
were taken into hospital the evening before the injection was to be given. They were given a mild
purge and only a light meal was allowed on the morning of the injection. Before treatment all were
carefully examined, special attention "being paid to
the circulatory, nervous, digestive, and urinary
EFFECTS FOLLOWING THE INJECTION OF SALVARSAN: Rigors,
a rise of temperature, headache, nausea and vomiting,
and occasionally diarrhoea, follow the administration
of the drug. The face and eyes "become congested and
the pulse and respiration accelerated. Cyanosis was
noted in a few cases. All these effects nave generally passed over "by the following day.
Action on Skin and Mucous Membranes : Applied, in
alkaline solution, to the unbroken skin or mucous
membranes produced no effects. If abrasions were
present slight irritation with hyperaemia was noted.
ACTION ON THE GASTRO-INTESTINAL TRACK: Salvarsan
is an irritant causing vomiting, and not infrequently
diarrhoea with colicy pains.
ACTION ON THE CIRCULATION: The cutaneous vessels of
the face and chest are dilated by the injection of
Salvarsan, and probably the vessels of the splanchnic
area are similarly affected. On perfusing the vessels of a frog with the drug it causes them to
The heart is accelerated in rate and may become
slightly irregular and even dilate. In the frog
the heart ceases in diastole, the ventricles being
first to cease contracting. In the dog a similar
effect is produced, the organ becoming engorged with
As a result of the weakening on the heart's
action,and the dilatation of vessels,the blood pressure falls.
ACTION ON THE WHITE BLOOD CORPUSCLES: A well marked
leucocytosis is set up, due to the increase of the
polymorphonuclear cells. The opsonic index is not
ACTION ON THE RED CELLS AND HAEMOGLOBIN: Salvarsan
causes a rapid increase in the red cells and haemoglobin where these are deficient, the increase being
more marked, at first in the haemoglobin.
THE COAGULATION TIME of the blood is not affected.
ACTION ON THE NERVOUS SYSTEM: Well marked headache
follows the injection of the drug, due probably to
its toxic action on the cells of the cortex. The
sensory and motor nerves are not affected by the drug.
ACTION ON THE URINARY SYSTEM: No bad effects were
observed. In one case albumin in the urine disappeared after the injection of Salvarsan.
ACTION ON METABOLISM: Rapid increase in weight and
a great improvement in general condition, with a
sense of well-being follows the injection of Salvarsan
ELIMINATION: Salvarsan is mainly excreted, in the
urine, but it is also present in vomited matter and
THERAPEUTIC EFFECTS: (1) IN SYPHILIS - Salvarsan
causes a rapid disappearance of the lesions in all
stages of the disease and accomplishes this in extremely short periods of time. The Wassermann reaction can, in all cases, be changed from a positive
to a negative.
A permanent cure is probably effected by the use
of Salvarsan alone with supplementing it with Mercury.
THERAPEUTIC EFFECTS: (2) IN LUPUS VULGARIS: Great benefit follows the
administration of the drug in this condition
THERAPEUTIC EFFECTS: (3) MALARIA: Good results follow its use in Malaria.,
especially the Benign Tertian form of the disease.
It may succeed in accomplishing a cure where quinine
has failed, this being especially marked in Malignant
THERAPEUTIC EFFECTS: (4) PIROPLASMO CANIS: The administration of Salvarsan
to dogs suffering from this condition gave rise to extremely satisfactory résulté, complete cure followed
the intravenous injection of the drug in the case of
two Irish terrier pups treated in this way. A great
field of usefulness in the treatment of this and the
allied conditions of Texas Fever, and Bilary Colic
in horses, is apparently open to the use of the drug.