Biological Sciences thesis and dissertation collection
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Recent Submissions
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Immune regulation of disease tolerance and immune priming in Drosophila
(The University of Edinburgh, 2022-05-26)To regain health following infection, hosts must not only identify and eliminate the source of infection, but also be able to reduce the resulting tissue damage in order to tolerate immunopathology. Compared to the mechanisms ... -
Molecular basis for the assembly and centromere targeting of the Mis18 complex: a key regulator of centromere inheritance
(The University of Edinburgh, 2019-07-06)[No Deposit Agreement] -
Environmental change impacts on ovine gastrointestinal parasitism
(The University of Edinburgh, 2019-07-06)[No Deposit Agreement] -
Analysis of released peptidases and their role in the transmission biology of African trypanosomes
(The University of Edinburgh, 2022-07-06)The protozoan parasite, Trypanosoma brucei causes devastating diseases in both humans and animals in sub-Saharan Africa. They live extracellularly and undergo a complex life cycle involving the mammalian host and the ... -
Nuclear spatial organization influences centromere identity
(The University of Edinburgh, 2022-04-13)Centromeres are specialized chromosomal domains that provide the attachment site for spindle microtubules emanating from opposite spindle pole bodies (SPBs; centrosome equivalent). Centromere identity is epigenetically ... -
Evolutionary ecology of biological rhythms in malaria parasites
(The University of Edinburgh, 2022-04-11)Biological rhythms are a ubiquitous feature of life and are assumed to allow organisms coordinate their activities with daily rhythms in the abiotic environment resulting from the rotation of the Earth every 24 hours. ... -
Struggling to keep the batteries charged: energy metabolism as a drug target in kinetoplastid parasites
(The University of Edinburgh, 2022-04-11)The kinetoplastid parasites Trypanosoma brucei, T. cruzi, and Leishmania spp. are responsible for a variety of human and animal diseases including human African trypanosomiasis (HAT), Chagas disease, the leishmaniasis, ... -
Decoding malaria T-cell responses using adaptive immune receptor repertoire sequencing
(The University of Edinburgh, 2022-04-04)Malaria continues to be a serious public health problem in many parts of the world, and progress in reducing the global malaria burden has stalled in recent years. Despite decades of research, current vaccine candidates ... -
Effect of environmental factors on inter-individual differences in Engystomops pustulosus and Xenopus laevis tadpole behaviour
(The University of Edinburgh, 2022-03-22)Inter-individual differences in behaviour contribute to the raw material on which natural selection can act and have important ecological and evolutionary consequences for a population. Behaviour can vary at the among and ... -
Computational analysis of single-cell dynamics: protein localisation, cell cycle, and metabolic adaptation
(The University of Edinburgh, 2022-03-22)Cells need to be able to adapt quickly to changes in nutrient availability in their environment in order to survive. Budding yeasts constitute a convenient model to study how eukaryotic cells respond to sudden environmental ... -
Genomic epidemiology of SARS-CoV-2: from outbreak investigations, to national and international surveillance efforts
(The University of Edinburgh, 2022-03-18)The response of the global genomics community to the SARS-CoV-2 pandemic has been unprecedented. At time of writing there are more than 3.7 million SARS-CoV-2 genome sequences shared publicly on GISAID (www.gisaid.org). ... -
Understanding interactions between Ramularia collo-cygni and barley leaf physiology to target improvements in host resistance and disease control strategy
(The University of Edinburgh, 2022-03-14)Ramularia Leaf Spot (RLS) is an increasingly problematic disease of barley. Control options are limited as the causal fungus, Ramularia collo-cygni, has developed resistance to several of the major fungicide groups. ... -
Role of thioredoxin isoforms in plant immunity
(The University of Edinburgh, 2022-03-14)Post-translational protein modifications (PTM) are key mechanisms to increase proteomic complexity and functional diversity to regulate crucial cellular processes precisely. The plant immune system comprises complex ... -
Understanding phytochrome regulation of plant growth and carbon resource management in Arabidopsis Thaliana
(The University of Edinburgh, 2022-03-14)Plantshave the ability to monitor fluctuations in their light environment constantlyand actively adjust their metabolism to cope with variations in light andcarbon (C) resource availability. Phytochromes (phys), red and ... -
Spatial regulation of microtubule-associated proteins by 14-3-3 in oocytes
(The University of Edinburgh, 2022-03-10)Oocytes have a large volume and yet must assemble a bipolar meiotic spindle specifically around the chromosomes. Recently, 14-3-3 was discovered to spatially regulate the spindle assembly factor Kinesin-14/Ncd in fly ... -
Investigating the role of the Rad51 regulation by Srs2 and Rad54 during DNA replication and repair
(The University of Edinburgh, 2022-03-07)DNA carries the information necessary for the continuity of life. However, its integrity is constantly threatened by genotoxic stress exerted by various exogenous and endogenous factors. DNA damage may lead to genetic ... -
Machine learning and large scale cancer omic data: decoding the biological mechanisms underpinning cancer
(The University of Edinburgh, 2022-03-03)Many of the mechanisms underpinning cancer risk and tumorigenesis are still not fully understood. However, the next-generation sequencing revolution and the rapid advances in big data analytics allow us to study cells and ... -
Natural and sexual selection on MHC genes in Soay sheep
(The University of Edinburgh, 2022-02-23)The major histocompatibility complex (MHC) is one of the most variable gene families in vertebrates. MHC molecules can recognize antigens from pathogens and signal immune cells to invoke an adaptive immune response. ... -
Functional analysis of proteasome-associated ubiquitin ligases in plants
(The University of Edinburgh, 2022-02-23)Degradation of intracellular proteins by the ubiquitin-proteasome system (UPS) is a sophisticated mechanism that begins with anchoring ubiquitin molecules to a substrate and ends with proteasome-dependent proteolysis. ... -
Investigating how RIF1 coordinates the timing of replication and the spatial distribution of late-replicating genomic regions
(The University of Edinburgh, 2022-02-23)In eukaryotes, the genome is organised into domains which are replicated at different times during S-phase. The order of replication of these domains, known as the “replication-timing (RT) program”, is transmitted from ...
