I. A survey of the literature dealing with anti -
malarial compounds is given, with special reference
to the relationship between activity and chemical
• II. Various unsuccessful attempts to synthesise
derivatives of 2:3- pyrido -4 hydroxy quinoline are
described, and the constitution of the compound
obtained from 2- chloro- pyri dine and anthranilic acid
• III. 2- Hydroxy- 4methyl -5:6- pyrido quinoline and 2 -'
methy1-4hydroxy -5:6- pyrido quinoline have been
synthesised. The hydroxyl groups in these compounds
have been replaced by piperidino, diethylaminoethylamino
and diethylaminopropylamino side chains.
• IV. The nitration of 2- methyl -4 hydroxy quinoline
and of 2:3- dimethyl -4 hydroxy quinoline has been
accomplished and the constitutions of the resulting
compounds have been established by synthesis as 6-
nitro-2- methyl -4 hydroxy quinoline and 6- nitro -2:3-
dimethyl-4- hydroxy quinoline.
• V. Various derivatives of 2-methyl-6-nitro
quinoline having a basic side chain in position 4
and of 4methy1 -6 -nitro quinoline having a basic
side chain in position 2 have been prepared. The
hydroxyl group in 2- methy1- 4- hydroxy- 6- acetylamino
quinoline has also been replaced by piperidino and
diethylaminoethylamino side chains.