The cellular geography of Aurora kinases
dc.contributor.author
Carmena, Mar
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dc.contributor.author
Earnshaw, William C.
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dc.coverage.spatial
13
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dc.date.accessioned
2005-02-16T16:05:28Z
dc.date.available
2005-02-16T16:05:28Z
dc.date.issued
2003-11
dc.description.abstract
Aurora is the name given to a family of highly conserved protein kinases with essential roles in
many aspects of cell division. Yeasts have a single Aurora kinase, whereas mammals have three:
Aurora A, B and C. During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore.
They also regulate signalling by the spindle-assembly checkpoint pathway and cytokinesis.
Perturbation of Aurora kinase expression or function might lead to cancer.
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dc.format.extent
369210 bytes
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dc.format.mimetype
application/pdf
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dc.identifier.citation
Carmena M, Earnshaw WC, NATURE REVIEWS MOLECULAR CELL BIOLOGY, 4 (11): 842-854 NOV 2003
dc.identifier.uri
doi:10.1038/nrm1245
dc.identifier.uri
http://www.nature.com/
dc.identifier.uri
http://hdl.handle.net/1842/703
dc.language.iso
en
dc.publisher
Nature Publishing Group
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dc.subject
Aurora kinases
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dc.subject
cytokinesis
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dc.subject
cell division
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dc.subject
Cancer
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dc.subject
cellular
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dc.subject
geography
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dc.title
The cellular geography of Aurora kinases
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dc.type
Article
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