Synthesis of some thiophen compounds, with notes on the metabolism of thienyl carboxylic acid and of thienylalanine, and on the physiological action of thienylethylamine.
dc.contributor.author
Easson, Alexander Peter Tawse
en
dc.date.accessioned
2018-09-13T15:51:45Z
dc.date.available
2018-09-13T15:51:45Z
dc.date.issued
1930
dc.description.abstract
en
dc.description.abstract
(1) In a brief introduction, the physical and
chemical properties of benzene and of thiophen
are compared and contrasted. A review of what
is known of the physiological behaviour of thiophen
and its compounds is given.
en
dc.description.abstract
(2) The preparation of thiophen by a method
similar to that of Steinkopf is described. The
efficiency attained was comparable with that reported by Steinkopf in his earlier experiments.
The method was found to be satisfactory for the
preparation of large quantities of thiophen.
en
dc.description.abstract
(3) The results are described of a number of
experiments in which different methods for the
preparation of -thiophenaldehyde were investigated.
A full description of the most satisfactory method
is given.
en
dc.description.abstract
(4) The syntheses of the following hitherto undescribed derivatives of thiophen are described: -
1. Amino methyl a- thienyl ketone hydrochloride.
2. Thienyl propionic acid.
3. Thienyl propioizarnide.
4-6. a-Thienyl- 13 -ethylamine; hydrochloride,
quaternary methiodide.
7. 3:4-methylene dioxy-benzal thienyl ethylamine.
8. Fórmyl thienylethylamine.
9. Azolactone of a-thienyl-a -benzoyl amino acrylic acid.
10. a-Thienyl- a-benzoylamino acrylic acid.
11. a-Thienyl- a-benzoylamino propionic acid.
12. a-Thenal hydantoin; 13. Acetyl derivative.
14. a-Thenyl hydantoin.
15. a-Thienyl-ß -alanine.
en
dc.description.abstract
Most of these have been analysed and
characterised.
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dc.description.abstract
(5) A. note on the results of pharmacological tests
of thienyl- ethylamine is given. The physiological
action is exactly similar to that of phenylethylamine.
en
dc.description.abstract
Results of a preliminary experiment on the
metabolism of thienylalanine are reported. There
are indications from this experiment that thienylalanine does not behave in the same way as phenyl - alanine . No definite conclusions, however, can
be drawn.
en
dc.identifier.uri
http://hdl.handle.net/1842/32096
dc.publisher
The University of Edinburgh
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dc.relation.ispartof
Annexe Thesis Digitisation Project 2018 Block 20
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dc.relation.isreferencedby
en
dc.title
Synthesis of some thiophen compounds, with notes on the metabolism of thienyl carboxylic acid and of thienylalanine, and on the physiological action of thienylethylamine.
en
dc.type
Thesis or Dissertation
en
dc.type.qualificationlevel
Doctoral
en
dc.type.qualificationname
PhD Doctor of Philosophy
en
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