Evaluation of a simplified technique for nerve repair by means of entubulation by flexible controlled release glass
dc.contributor.author
Jeans, Lindsay Ann
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dc.date.accessioned
2018-03-29T12:17:30Z
dc.date.available
2018-03-29T12:17:30Z
dc.date.issued
2006
dc.description.abstract
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dc.description.abstract
The experiments presented in this thesis are a study in which the use of a
biodegradable glass wrap was compared with microsurgical epineurial suturing as a
means of repairing cleanly divided median nerves in a sheep model.
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dc.description.abstract
Twelve sheep were used in a control group and in each of four repair groups in which
the following procedures were carried out:
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dc.description.abstract
1. Neurotmesis and repair using microsurgically placed epineurial sutures of
10/0 polyamide
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dc.description.abstract
2. Neurotmesis and repair by entubulation with the biodegradable glass wrap
secured by 6/0 polyglactin macrosutures
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dc.description.abstract
3. Neurotmesis and repair by entubulation with the biodegradable glass wrap
secured by fibrin (Tisseel) glue
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dc.description.abstract
4. Neurotmesis and repair by entubulation with the biodegradable glass wrap
secured with polycaprolactone glue.
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dc.description.abstract
No gap was left between the proximal and distal stumps. Electrophysiological tests
on the median nerve, flexor carpi radialis muscle and flexor digitorum superficialis
muscle were carried out seven months after the repair and a portion of the median
nerve distal to the repair site was excised for morphometric examination after all
electrophysiological testing had been completed.
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dc.description.abstract
The main conclusions of the present study were:
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dc.description.abstract
1. Nerves repaired with the biodegradable glass wrap and fibrin glue displayed
distal neuronal regeneration that was no different from that which occurred
after a tensionless microsurgical epineurial suture. This biodegradable glass
wrap, secured with fibrin (Tisseel) glue, could therefore be used in humans to
repair simple nerve divisions.
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dc.description.abstract
2. Using the wrap in nerve repair is simple and is quicker and less expensive
than microsurgical epineurial suture.
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dc.description.abstract
3. Nerve regeneration after nerve repair could be assessed in humans by
measuring maximum conduction velocity (CVmax) (m s⁻¹) and transcutaneous
stimulated jitter (TSJ) (μs)
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dc.identifier.uri
http://hdl.handle.net/1842/29180
dc.publisher
The University of Edinburgh
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dc.relation.ispartof
Annexe Thesis Digitisation Project 2018 Block 17
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dc.relation.isreferencedby
Already catalogued
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dc.title
Evaluation of a simplified technique for nerve repair by means of entubulation by flexible controlled release glass
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dc.type
Thesis or Dissertation
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dc.type.qualificationlevel
Doctoral
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dc.type.qualificationname
MD Doctor of Medicine
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