Relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging
dc.contributor.advisor
Ritchie, Craig
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dc.contributor.advisor
Muniz Terrera, Graciela
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dc.contributor.author
Topiwala, Hinesh
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dc.contributor.sponsor
European Commission
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dc.date.accessioned
2020-01-31T14:52:33Z
dc.date.available
2020-01-31T14:52:33Z
dc.date.issued
2020-01-22
dc.description.abstract
Introduction: Studies have demonstrated a relationship between
neurodegeneration and lifestyle factors. Neurodegeneration in midlife (40 –
59 years old) can be assessed using neuroimaging. The aim of the thesis
was to evaluate the relationship between lifestyle factors and
neurodegeneration in midlife as expressed on arterial spin labelling and
structural magnetic resonance imaging.
Methods: A systematic review of the relationship between lifestyle and
neurodegeneration in midlife as expressed on functional magnetic resonance
imaging (fMRI) was undertaken. Additionally, the impact of lifestyle on the
arterial spin labelling (ASL) and structural magnetic resonance imaging
(sMRI) expression of neurodegeneration in a midlife cohort was analytically
assessed.
Results: Seven lifestyle factors associated with neurodegeneration in midlife
as expressed on fMRI were identified by the systematic review. Using data
from the PREVENT Dementia cohort, linear regression analysis
demonstrated multiple associations between lifestyle and neurodegeneration
in midlife as expressed on ASL and sMRI.
Discussion: The findings from this thesis can guide future analysis of
PREVENT Dementia cohort data. Furthermore, the findings from this thesis
could be shared with the public through the NHS Health Check in England
and the Keep Well Programme in Scotland, to help promote lifestyle
interventions to optimise brain health in midlife.
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dc.identifier.uri
https://hdl.handle.net/1842/36715
dc.identifier.uri
http://dx.doi.org/10.7488/era/22
dc.language.iso
en
dc.publisher
The University of Edinburgh
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dc.relation.hasversion
Topiwala H, Terrera GM, Stirland L, Saunderson K, Russ TC, Dozier MF, et al. Lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging: A systematic review. Alzheimer's & Dementia: Translational Research & Clinical Interventions. 2018.
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dc.subject
neurodegeneration
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dc.subject
neuroprotection
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dc.subject
Magnetic Resonance Imaging
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dc.subject
life style
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dc.subject
middle aged
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dc.title
Relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging
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dc.type
Thesis or Dissertation
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dc.type.qualificationlevel
Doctoral
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dc.type.qualificationname
MD Doctor of Medicine
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