Wade, Henry

2019-02-15T14:25:36Z

2019-02-15T14:25:36Z

1907

The conclusions concerning the nature of Infective Sarcoma which have been arrived at, as a result of this investigation are:- 1. That Infective Sarcoma is a general disease characterised by the production of a local lesion, possessing the histological structure of an alveolar sarcoma. 2. That it is caused by an intracellular virus, conveyed by contagion from a living cell to a living cell. 3. That the tumours formed after natural infection, probably consist of cells entirely derived from the tissues of the host. 4. That the nature of the virus cannot be detected, and (a) cannot be revealed by any method of staining. (b) does not pass through a Berkefeld Filter. (c) is not an ultramicroscopical microorganism. (d) cannot be isolated apart from the tumour. (e) is not a Spirochete. 5. That the disease can be reproduced readily by subcutaneous inoculation into animals of the same species. 6. That by the same method, it can be reproduced in the fox. 7. That the tumours following subcutaneous inoculation are created from the cells introduced, live, and by a process of direct contagion, lead to the formation of additional tumour cells, from the connective tissue cells of the host. 8. That it grows by multiplication of the cells thus formed, combined with a limited formation of additional tumour cells, from the tissues of the/ 200. the host. 9. That this latter ceases, with the development of the power of increased resistance on the part of the host, and a capsule is thus formed around the tumour. 10. That the tumours disappear by gradual cytolysis associated with the presence of, and probably caused by, lymphocytes and polyblasts. 11. That the growth of the tumour is accompanied by a gradual increase in the number of mononucleated cells in the circulation. 12. That immunity follows spontaneous recovery. 13. That this is brought about by a similar process, occupying a much shorter duration of time - a cytolysis of the tumour cells accompanied by, and probably arising from, the presence of lymphocytes and polyblasts. 14. The growth of the tumour is associated with the development of a toxin, which can be isolated from it by filtration, and produces interstitial nephritis. 15. That the results of this investigation, emphasise the present unsatisfactory class faction of neoplasms, which include a heterogeneous collection of pathological processes, and indicates the probability that, in the near future, a differentiation will be possible, of processes that are really neoplastic, from those, that are merely reactive attempts by the host against an invading virus.

http://hdl.handle.net/1842/34301

The University of Edinburgh

Annexe Thesis Digitisation Project 2019 Block 22

A contribution to the problem of cancer research based upon the results of an experimental investigation of infective sarcoma of the dog

Thesis or Dissertation

Doctoral

MD Doctor of Medicine