Experiments in carcinogenesis, 1939-1944

Abstract

In submitting this thesis for the degree of Doctor of Medicine, the following; five papers and their commentaries are presented as a series of experiments in carcinogenesis carried out, under war-time conditions, in the Wilkie Surgical Research Laboratory, University of Edinburgh. They record the evolution of an outlook rather than the solution of a problem; though in the course of these investigations, several points of material interest to the cancer worker have been clarified. Finally, the problem is summed up in general terms and a bridgehead for further work is established.• Paper I. "Sulphydryl compounds and wound repair." (1940). Reprinted from the BRITISH MEDICAL JOURNAL, October 19th, 1940, vol. ii, p. 516

• Paper II. "Stimulation and inhibition of connective tissue in mice following injection of benzpyrene." (1941). Reprinted from The British Journal of Experimental Pathology, 1941, Vol. XXII, p. 24.

• Paper III. "Retarding effect of glyceraldehyde on benzpyrene sarcoma formation in mice." (1944). By J. F. Riley and F. Pettigrew. Reprinted from CANCER RESEARCH, VOLUME 4, NUMBER 8, AUGUST 1944

• Paper IV. "Acceleration by means of prolonged mechanical irritation, of carcinogenesis in the skin of mice painted with 1,2,5,6 - dibenzanthracene." (1945). By J. F. Riley and F. Pettigrew. Reprinted from The British Journal of Experimental Pathology, 1945, Vol. XXVI, p. 63.

• Paper V. "Experimental Cancer Research." (1944). Reprinted from the EDINBURGH MEDICAL JOURNAL, VOL. LI., p. 290, 1944.