Marshall, Ian

Thrippleton, Michael

Parikh, Jehill

2013-11-08T13:53:46Z

2013-11-08T13:53:46Z

2013-07-06

The study of brain temperature is important for a number of clinical conditions such as stroke, traumatic brain injury, schizophrenia and birth asphyxia (for neonates). A direct method to estimate brain temperature non-invasively will allow assessment of brain thermoregulation and its variation in clinical conditions. Magnetic resonance imaging is a powerful technique widely used for diagnosis of a range of neurological conditions. All magnetic resonance procedures involve manipulation of the hydrogen nuclei in the water molecules of the human body. The resonance frequency of the water molecules is temperature dependent, thus MR thermometry is a powerful tool for non-invasive temperature measurement. Using internal reference MR spectroscopic imaging (MRSI), absolute brain temperature maps can be estimated. However a number of temperature independent factors influence MRSI data acquisition, thus a thorough validation is necessary and is the focus of this PhD study. In this PhD study using phantom (test object) studies it was shown that optimization of the MRSI pulse sequence is necessary to reduce systematic error in temperature maps and extensive in-vitro validation of MRSI temperature mapping was performed. A custom made temperature-controlled phantom was designed for this purpose and is presented in this thesis. MRSI data acquired from healthy (young and elderly) volunteers was employed to assess regional brain temperature variations and repeatability. Finally, the feasibility of employing fast echo planar spectroscopic imaging for volumetric MRSI temperature mapping will be presented in this thesis.

http://hdl.handle.net/1842/8082

en

The University of Edinburgh

Parikh J and Marshall I, A simple and effective method for QA of MRS data Proceeding of SINAPSE and IPEM Multicentre MRI day, (Edinburgh, 2010).

Parikh J and Marshall I, MR spectroscopic imaging and brain temperature mapping, Proceedings of SINAPSE Annual Scientific Meeting, (Edinburgh, 2010) and Proceedings of British Chapter of International Society of Magnetic Resonance in Medicine, (Nottingham, 2010).

Parikh J, Marshall I, Murray C, Allerhand M, Harris B, Thrippleton M, Wardlaw J, Deary I, Andrews J and Starr J. Regional metabolites and brain temperature measured using 1H MRSI: A pilot study on healthy elderly volunteers from Lothian Birth Cohort 1936 (LBC1936). Proceedings of ESMRMB (Leipzig, 2011), P285.

Parikh J, Michael T and Marshall I, Systematic error in MRSI based brain temperature mapping, Proceedings of British Chapter of International Society of Magnetic Resonance in Medicine, (Manchester, 2011), P66.

Parikh J, Thrippleton M and Marshall I, Reduction of systematic error in MRSI based brain temperature mapping, Proceedings of 20th International Society of Magnetic Resonance in Medicine, (Melbourne, 2012).

Thrippleton M, Parikh J, Hammer S, Harris B, Andrews PJ, Wardlaw JM and Marshall I, A Temperature controlled phantom for MR spectroscopic imaging. Proceedings of British Chapter of International Society of Magnetic Resonance in Medicine, (Cambridge, 2012).

Wardlaw JM, Brindle W, Casado AM, Shuler K, Henderson M, Thomas B, Macfarlane J, Muñoz Maniega S, Lymer K, Morris Z, Pernet C, Nailon W, Ahearn T, Mumuni AN, Mugruza C, McLean J, Chakirova G, Tao YT, Simpson J, Stanfield AC, Johnston H, Parikh J, Royle NA, De Wilde J, Bastin ME, Weir N, Farrall A, Valdes Hernandez MC; The SINAPSE Collaborative Group. A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research, European Radiology 2012.

brain temperature

MRI

magnetic resonance imaging

spectroscopy

Measurement of brain temperature using magnetic resonance spectroscopic imaging

Thesis or Dissertation

Doctoral

PhD Doctor of Philosophy