Investigation into the mechanism behind the photothermal switch in cell expansion
dc.contributor.advisor
Grima, Ramon
en
dc.contributor.advisor
Halliday, Karen
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dc.contributor.author
Jones, Harriet Josephine
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dc.contributor.sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
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dc.date.accessioned
2017-01-12T09:55:03Z
dc.date.available
2017-01-12T09:55:03Z
dc.date.issued
2016-06-28
dc.description.abstract
Light signalling mechanisms are crucial for plant adaptation to environmental
changes: it has been found that both light and temperature cues are interpreted by
closely interacting signalling pathways. In Arabidopsis thaliana, the seedling
hypocotyl has emerged as an ideal model system to study light and temperature control
of cell expansion.
The light sensitivity is affected by the light intensity (fluence rate), an illustration of
which is exemplified in the fluence rate response curve, and also the quality of that
light (i.e. the ratio of red: far-red wavelengths of light). Here I have elucidated the
phytochrome B (phyB) signalling mechanism in great detail and subsequently created
a mathematical model of the red-light signalling pathway. This model is further
extended to include changes within the ambient temperature range. Through
application of stochastic modelling techniques it was possible to demonstrate the
importance of dark reversion within the phyB mechanism in a diurnal cycle.
Further, by considering alternative modelling methods and applying a highly
integrated mathematical and experimental approach, it has been possible to show how
the integration of light and temperature signals drives a molecular switch in
transcriptional activity and hence control of cell expansion. This work highlights the
importance of a multidisciplinary approach to molecular biology and describes the
significance of signal convergence on molecular signalling.
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dc.identifier.uri
http://hdl.handle.net/1842/19522
dc.language.iso
en
dc.publisher
The University of Edinburgh
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dc.relation.hasversion
Johansson H, Jones HJ, Foreman J, Hemsted JR, Stewart K, Grima R, Halliday KJ. 2014. Arabidopsis cell expansion is controlled by a photothermal switch. Nat Commun 5: 4848.
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dc.rights.embargodate
2100-12-31
dc.subject
modelling
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dc.subject
phytochrome
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dc.title
Investigation into the mechanism behind the photothermal switch in cell expansion
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dc.type
Thesis or Dissertation
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dc.type.qualificationlevel
Doctoral
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dc.type.qualificationname
PhD Doctor of Philosophy
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dcterms.accessRights
Restricted Access
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