On adrenalin hyperglycaemia

Abstract

Subject of Present Investigation: (1) That modifications, if any, take place in the curve of adrenalin hyperglycaemia when moderately large doses are given subcutaneously at frequent intervals? (2) Can the daily variation in adrenalin glycosuria, the existence of which is already proved, be accounted for by variations in the blood sugar response, or by variations in the amount of urine passed?(1) Previous literature on adrenalin hyperglycaemia is reviewed and discussed..(2) Reports of investigations into the effect of daily subcutaneous injection are minutely examined and criticised.(3) Experiments are described in which the curve of hyperglycaemia is examined from time to time during daily subcutaneous administration of moderate doses of adrenalin in rabbits.(4) It is concluded (a) that the curve of adrenalin hyperglycaemia is not markedly modified after repeated daily injection, though minor variations constantly occur; (b) that the daily variations of adrenalin glycosuria cannot be related to the degree and duration of hyperglycaemia or to the amount of urine passed.