Some aspects of leucocyte metabolism: "in vitro" effects of drugs inducing agranulocytosis on separated human lymphocytes and polymorphonuclear leucocytes
dc.contributor.author
McCurrach, Paul H.
en
dc.date.accessioned
2019-02-15T14:35:52Z
dc.date.available
2019-02-15T14:35:52Z
dc.date.issued
1968
dc.description.abstract
en
dc.description.abstract
This work was carried out in order to investigate the actions
of drugs known to induce agranulocytosis on certain metabolic
reactions of human leucocytes. Lymphocytes and polymorphonuclear leucocytes (PMN) were separated "in vitro" from samples
of normal human blood, utilising the property of PMN whereby they
will adhere to siliconed glass surfaces while lymphocytes do not
adhere. The respiration and lactic acid production of the separated
leucocytes was measured using manometric and enzymic methods
respectively. It was found that drugs inducing predominately
agranulocytosis - chlorpromazine, amidopyrine, and thiouracil -
inhibited PMN respiration by 20% at concentrations which occur
"in vivo" under normal therapeutic conditions. Drugs inducing
both agranulocytosis and aplastic anaemia - phenylbutazone and
chloramphenicol - showed little inhibitory activity on PMN
respiration. No drugs exerted any apparent effect on
lymphocyte respiration and on PMN lactic acid production. The
significance of these results was discussed.
en
dc.identifier.uri
http://hdl.handle.net/1842/35213
dc.publisher
The University of Edinburgh
en
dc.relation.ispartof
Annexe Thesis Digitisation Project 2019 Block 22
en
dc.relation.isreferencedby
en
dc.title
Some aspects of leucocyte metabolism: "in vitro" effects of drugs inducing agranulocytosis on separated human lymphocytes and polymorphonuclear leucocytes
en
dc.type
Thesis or Dissertation
en
dc.type.qualificationlevel
Doctoral
en
dc.type.qualificationname
PhD Doctor of Philosophy
en
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