Leigh, David

Cockroft, Scott

Campbell, Christopher James

Engineering and Physical Sciences Research Council (EPSRC)

2016-10-28T13:45:40Z

2016-10-28T13:45:40Z

2013-11-28

The study of topologically complex molecules is necessary to better understand the knotted architectures that abound within Nature and are vital in the functioning of DNA and proteins. Metal based template strategies have played a key role in the successful synthesis of a number of interwoven structures constructed from small molecule building blocks, however novel methodology is crucial for the expansion of this fascinating field of chemistry. The strategy of linking the ends of a cyclic helicate has been developed within the Leigh group and applied with great success to the synthesis of the first molecular pentafoil knot. This thesis presents the application of this strategy to the high yielding synthesis of a molecular Solomon link. In depth studies of the self-assembly of a pentafoil knot and self-sorting reactions are also presented, offering insights into the nontrivial self-assembly of these topologically complex molecules.

http://hdl.handle.net/1842/17071

en

The University of Edinburgh

“Strategies and Tactics for the Metal-Directed Synthesis of Rotaxanes, Knots, Catenanes and Higher Order Links”, J. E. Beves, B. A. Blight, C. J. Campbell, D. A. Leigh and R. T. McBurney, Angew. Chem. Int. Ed., 2011, 50, 9260-9327.

“Template synthesis of molecular knots”, J.-F. Ayme, J. E. Beves, C. J. Campbell and D. A. Leigh, Chem Soc Rev, 2013, 42, 1700-1712.

“Tetrameric Cyclic Double Helicates as a Scaffold for a Molecular Solomon Link”, J. E. Beves, C. J. Campbell, D. A. Leigh and R. G. Pritchard, Angew. Chem. Int. Ed., 2013, 52, 6464–6467.

2100-12-31

interlocked

Solomon link

catenane

Synthesis of topologically complex molecules

Thesis or Dissertation

Doctoral

PhD Doctor of Philosophy

Restricted Access