Lawson, J. B.

Kajume, Julius Kithinji

British Council

2024-02-19T15:32:40Z

2024-02-19T15:32:40Z

1980

The excretion of oxytetracycline and penicillin in bovine milk following their intramuscular administration was demonstrated by bromocresol purple test ("Intertest”). Dosages of 1200 mg of oxytetracycline hydrochloride and 5 mega units of penicillin (crystapen) per cow both resulted in detectable residues in milk for 24-32 hours following administration,. The minimum concentration of oxytetracycline in the serum which resulted in detectable residues in milk was 2.5 mg/ml while that of penicillin was 0.16iu/ml. Antibiotic concentrations in the serum were determined by the tube dilution method. The effect of heat (boiling at 100°C for 10 minutes) on known concentrations of oxytetracycline and penicillin added to milk was determined using a modified disc assay method with the Oxford (Heatley) Strain of Staphylococcus aureus (NCTC 6571) as the test organism. Oxytetracycline was partially inactivated with a mean antibiotic activity loss of 37.8% whereas penicillin was not inactivated to any noticeable extent.

https://hdl.handle.net/1842/41464

http://dx.doi.org/10.7488/era/4196

The University of Edinburgh

Already catalogued

Annexe MSc Digitisation Project 2022 Block 43

Observations on antibiotic residues in milk

Thesis or Dissertation

Masters

MSc Master of Science