Ectodysplasin signaling in cutaneous appendage development: Dose, duration and diversity

Abstract

The development of several skin appendages is guided by prenatal Ectodysplasin signalling. Cui et al. (this issue, 2009) report on the dose and duration of Ectodysplasin signalling required for the maintenance and morphogenesis of different appendages. They find that achievement of an intimate arrangement between epithelial and mesenchymal cell populations correlates with the acquisition of autonomy from Ectodysplasin stimulation.