Edinburgh Research Archive

Enantioselective Rhodium-Catalyzed Allylation of Cyclic Imines with Potassium Allyltrifluoroborates

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dc.contributor.author
Hepburn, Hamish B.
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dc.contributor.author
Chotsaeng, Nawasit
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dc.contributor.author
Luo, Yunfei
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dc.contributor.author
Lam, Hon Wai
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dc.date.accessioned
2013-08-13T09:56:44Z
dc.date.available
2013-08-13T09:56:44Z
dc.date.issued
2013
dc.description.abstract
This Article presents further examples of the enantioselective rhodium-catalyzed addition of potassium allyltrifluoroborates to cyclic imines. A wide range of substituted allyltrifluoroborates are compatible with this process, and provide protected homoallylic amines with high levels of diastereo- and enantioselection. The reactions display a strong preference for carbon‒carbon bond formation at the more substituted terminus of the allyl fragment of the allyltrifluoroborate, regardless of the position of the boron atom. Representative examples of manipulation of the products are also described.
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dc.identifier.citation
early on-line
dc.identifier.issn
0039-7881
dc.identifier.uri
http://hdl.handle.net/1842/7643
dc.language.iso
en
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SYNTHESIS
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dc.subject
allyltrifluoroborates
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dc.subject
asymmetric catalysis
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dc.subject
enantioselectivity
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dc.subject
imines
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dc.subject
rhodium
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dc.title
Enantioselective Rhodium-Catalyzed Allylation of Cyclic Imines with Potassium Allyltrifluoroborates
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dc.type
Article
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