Some organic arsenic compounds of possible therapeutic activity

Abstract

1. Some benzene derivatives containing long aliphatic side chains have been prepared. Such amino compounds did not take part in the Bart reaction.

2. A series of N-substituted aminomalonamide phenyl arsinic acids have been prepared and their therapeutic activity tested on an experimental trypanosome infection in mice.

3. Several alkyl bromomalonamides have been prepared but these would not condense with parsanilic acid.

4. Attempts to prepare succinamide arsinic acids and the utilisation of o-arsanilic acid in the general condensation met with failure.

5. A short study has been commenced in the diphenyl ether series and a few new compounds prepared.