(1) In a brief introduction, the physical and
chemical properties of benzene and of thiophen
are compared and contrasted. A review of what
is known of the physiological behaviour of thiophen
and its compounds is given.
(2) The preparation of thiophen by a method
similar to that of Steinkopf is described. The
efficiency attained was comparable with that reported by Steinkopf in his earlier experiments.
The method was found to be satisfactory for the
preparation of large quantities of thiophen.
(3) The results are described of a number of
experiments in which different methods for the
preparation of -thiophenaldehyde were investigated.
A full description of the most satisfactory method
Most of these have been analysed and
(5) A. note on the results of pharmacological tests
of thienyl- ethylamine is given. The physiological
action is exactly similar to that of phenylethylamine.
Results of a preliminary experiment on the
metabolism of thienylalanine are reported. There
are indications from this experiment that thienylalanine does not behave in the same way as phenyl - alanine . No definite conclusions, however, can