Jeffrey, James Sneddon

2019-02-15T14:31:09Z

2019-02-15T14:31:09Z

1939

1. "Regional ileitis" is the name given by Crohn in 1932 to a hitherto unclassified affection of the lower ileum. 2. The condition has distinctive pathological features of its own. The chronic phase of the disease has been fully examined, but little is known of the acute phase or the earliest lesion. 3. A broader conception of the disease has resulted from the co- relation with regional ileitis of the combined diseases jejuno-ileitis, and ileo-colitis 4. The relationship of regional ileitis to other benign non-specific intestinal granulomata has been discussed, and the aetiology of these granulomata considered. 5. The clinical features of the disease have been described. In the acuto phase the features are not distinguishable from those of acute appendicitis. In the chronic stage there are certain characteristic symptoms and signs. 6. The differential diagnosis of regional ileitis has been considered, and the clinical and radiological aids to diagnosis indicated. 7. Treatment should be conservative in the acute phase; in the chronic stage radical excision should be performed. 8. Seven original cases of regional ileitis have been described, and the pathological features considered in detail. 9. An investigation has been made of all the cases involving ileum or caecum, or both, from one charge in the Royal Infirmary. There is no evidence that regional ileitis has been going unrecognised in past years. 10. The aetiology of the condition has been discussed) Tuberculosis, dysentery, and the common intestinal organisms can be excluded as primary aetiological factors. The disease remains one of unknown aetiology. 11. Certain experimental attempts to reproduce ileitis in animals have not been successful, and as yet there is no experimental evidence that the condition is caused by the common organisms or an ultra- filterable virus. Suggestions for further experiments have been put forward. 12. The grounds for concluding that regional ileitis may justifiably be considered a separate entity, and to be occurring more commonly than in the past, have been put forward; along with suggestions for diagnostic criteria.

http://hdl.handle.net/1842/34778

The University of Edinburgh

Annexe Thesis Digitisation Project 2019 Block 22

Regional ileitis: a clinical and experimental study

Thesis or Dissertation

Doctoral

MD Doctor of Medicine