1. "Regional ileitis" is the name given by Crohn in
1932 to a hitherto unclassified affection of the
2. The condition has distinctive pathological features of its own. The chronic phase of the disease
has been fully examined, but little is known of the acute phase or the earliest lesion.
3. A broader conception of the disease has resulted
from the co- relation with regional ileitis of the
combined diseases jejuno-ileitis, and ileo-colitis
4. The relationship of regional ileitis to other
benign non-specific intestinal granulomata has
been discussed, and the aetiology of these granulomata
5. The clinical features of the disease have been
described. In the acuto phase the features are
not distinguishable from those of acute appendicitis.
In the chronic stage there are certain
characteristic symptoms and signs.
6. The differential diagnosis of regional ileitis
has been considered, and the clinical and radiological
aids to diagnosis indicated.
7. Treatment should be conservative in the acute
phase; in the chronic stage radical excision
should be performed.
8. Seven original cases of regional ileitis have
been described, and the pathological features
considered in detail.
9. An investigation has been made of all the cases
involving ileum or caecum, or both, from one
charge in the Royal Infirmary. There is no evidence
that regional ileitis has been going unrecognised in past years.
10. The aetiology of the condition has been discussed)
Tuberculosis, dysentery, and the common intestinal
organisms can be excluded as primary aetiological
factors. The disease remains one of unknown
11. Certain experimental attempts to reproduce ileitis
in animals have not been successful, and as yet
there is no experimental evidence that the condition
is caused by the common organisms or an
ultra- filterable virus. Suggestions for further
experiments have been put forward.
12. The grounds for concluding that regional ileitis
may justifiably be considered a separate entity,
and to be occurring more commonly than in the
past, have been put forward; along with suggestions
for diagnostic criteria.